Gamma-aminobutyric acid receptor subunit alpha-1

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GABRA1
Identifiers
Aliases GABRA1, ECA4, EIEE19, EJM, EJM5, gamma-aminobutyric acid type A receptor alpha1 subunit
External IDs MGI: 95613 HomoloGene: 629 GeneCards: 2554
RNA expression pattern
PBB GE GABRA1 206678 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_010250

RefSeq (protein)

NP_000797.2
NP_001121115.1
NP_001121116.1
NP_001121117.1
NP_001121120.1

NP_034380.1

Location (UCSC) Chr 5: 161.85 – 161.9 Mb Chr 11: 42.13 – 42.18 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Gamma-aminobutyric acid receptor subunit alpha-1 is a protein that in humans is encoded by the GABRA1 gene.[3]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.[4]

The GABRA1 receptor is the specific target of the z-drug class of nonbenzodiazepine hypnotic agents and is responsible for their hypnotic and hallucinogenic effects.

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Johnson KJ, Sander T, Hicks AA, van Marle A, Janz D, Mullan MJ, Riley BP, Darlison MG (Dec 1992). "Confirmation of the localization of the human GABAA receptor alpha 1-subunit gene (GABRA1) to distal 5q by linkage analysis". Genomics. 14 (3): 745–8. doi:10.1016/S0888-7543(05)80178-8. PMID 1330891. 
  4. ^ "Entrez Gene: GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.