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Aliases GABRA6
External IDs MGI: 95618 HomoloGene: 20220 GeneCards: 2559
Targeted by Drug
gaboxadol, Isoguvacine, Isonipecotic acid, muscimol, bretazenil, Ro15-4513, flumazenil, bicuculline, picrotoxin, CGS8216[1]
RNA expression pattern
PBB GE GABRA6 207182 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 5: 161.55 – 161.7 Mb Chr 11: 42.31 – 42.32 Mb
PubMed search [2] [3]
View/Edit Human View/Edit Mouse

Gamma-aminobutyric acid receptor subunit alpha-6 is a protein that in humans is encoded by the GABRA6 gene.[4][5]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.[5]

One study has found a genetic variant in the gene to be associated with the personality trait neuroticism.[6]

See also[edit]


  1. ^ "Drugs that physically interact with Gamma-aminobutyric acid receptor subunit alpha-6 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Hicks AA, Bailey ME, Riley BP, Kamphuis W, Siciliano MJ, Johnson KJ, Darlison MG (Aug 1994). "Further evidence for clustering of human GABAA receptor subunit genes: localization of the alpha 6-subunit gene (GABRA6) to distal chromosome 5q by linkage analysis". Genomics. 20 (2): 285–8. doi:10.1006/geno.1994.1167. PMID 8020978. 
  5. ^ a b "Entrez Gene: GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6". 
  6. ^ Srijan Sen; Sandra Villafuerte; Randolph Nesse; Scott F. Stoltenberg; Jeffrey Hopcian; Lillian Gleiberman; Alan Weder & Margit Burmeister (February 2004). "Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism". Biological Psychiatry. 55 (3): 244–249. doi:10.1016/j.biopsych.2003.08.006. PMID 14744464. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.