GABRA6

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GABRA6
Identifiers
Aliases GABRA6
External IDs MGI: 95618 HomoloGene: 20220 GeneCards: 2559
RNA expression pattern
PBB GE GABRA6 207182 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000811

NM_001099641
NM_008068

RefSeq (protein)

NP_000802.2

NP_001093111.1
NP_032094.2

Location (UCSC) Chr 5: 161.55 – 161.7 Mb Chr 11: 42.31 – 42.32 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Gamma-aminobutyric acid receptor subunit alpha-6 is a protein that in humans is encoded by the GABRA6 gene.[1][2]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.[2]

One study has found a genetic variant in the gene to be associated with the personality trait neuroticism.[3]

See also[edit]

References[edit]

  1. ^ Hicks AA, Bailey ME, Riley BP, Kamphuis W, Siciliano MJ, Johnson KJ, Darlison MG (Aug 1994). "Further evidence for clustering of human GABAA receptor subunit genes: localization of the alpha 6-subunit gene (GABRA6) to distal chromosome 5q by linkage analysis". Genomics 20 (2): 285–8. doi:10.1006/geno.1994.1167. PMID 8020978. 
  2. ^ a b "Entrez Gene: GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6". 
  3. ^ Srijan Sen; Sandra Villafuerte; Randolph Nesse; Scott F. Stoltenberg; Jeffrey Hopcian; Lillian Gleiberman; Alan Weder & Margit Burmeister (February 2004). "Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism". Biological Psychiatry 55 (3): 244–249. doi:10.1016/j.biopsych.2003.08.006. PMID 14744464. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.