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Gamma-aminobutyric acid (GABA) A receptor, epsilon
Symbol GABRE
External IDs OMIM300093 MGI1330235 HomoloGene68425 IUPHAR: 417 ChEMBL: 4635 GeneCards: GABRE Gene
RNA expression pattern
PBB GE GABRE 204537 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2564 14404
Ensembl ENSG00000102287 ENSMUSG00000031340
UniProt P78334 A2AMW3
RefSeq (mRNA) NM_004961 NM_017369
RefSeq (protein) NP_004952 NP_059065
Location (UCSC) Chr X:
151.95 – 151.97 Mb
Chr X:
72.26 – 72.27 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid receptor subunit epsilon is a protein that in humans is encoded by the GABRE gene.[1][2][3]

The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]

Brainstem expression of ε subunit-containing GABAA receptors is upregulated during pregnancy, particularly in the ventral respiratory group.[4]

See also[edit]


  1. ^ Davies PA, Hanna MC, Hales TG, Kirkness EF (Mar 1997). "Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit". Nature 385 (6619): 820–3. doi:10.1038/385820a0. PMID 9039914. 
  2. ^ Garret M, Bascles L, Boue-Grabot E, Sartor P, Charron G, Bloch B, Margolskee RF (Apr 1997). "An mRNA encoding a putative GABA-gated chloride channel is expressed in the human cardiac conduction system". J Neurochem 68 (4): 1382–9. doi:10.1046/j.1471-4159.1997.68041382.x. PMID 9084408. 
  3. ^ a b "Entrez Gene: GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon". 
  4. ^ Hengen KB et al. (2012). PMID 22303446

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.