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Gamma-aminobutyric acid (GABA) A receptor, gamma 2
Symbols GABRG2 ; CAE2; ECA2; GEFSP3
External IDs OMIM137164 MGI95623 HomoloGene22443 IUPHAR: 414 ChEMBL: 1788 GeneCards: GABRG2 Gene
RNA expression pattern
PBB GE GABRG2 206849 at tn.png
More reference expression data
Species Human Mouse
Entrez 2566 14406
Ensembl ENSG00000113327 ENSMUSG00000020436
UniProt P18507 P22723
RefSeq (mRNA) NM_000816 NM_008073
RefSeq (protein) NP_000807 NP_032099
Location (UCSC) Chr 5:
162.07 – 162.16 Mb
Chr 11:
41.91 – 42 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid receptor subunit gamma-2 is a protein that in humans is encoded by the GABRG2 gene.

Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates neuronal inhibition by binding to GABA receptors. The type A GABA receptors are pentameric chloride channels assembled from among many genetic variants of GABA(A) subunits. This gene encodes the gamma 2 subunit of GABA(A) receptor. Mutations in this gene have been associated with epilepsy and febrile seizures. Alternative splicing of this gene results in transcript variants encoding different isoforms.[1]


GABRG2 has been shown to interact with GABARAP[2][3][4] and Dopamine receptor D5.[5]

See also[edit]


  1. ^ "Entrez Gene: GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2". 
  2. ^ Nymann-Andersen, Jesper; Wang Hongbing; Chen Li; Kittler Josef T; Moss Stephen J; Olsen Richard W (March 2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors". J. Neurochem. (England) 80 (5): 815–23. doi:10.1046/j.0022-3042.2002.00762.x. ISSN 0022-3042. PMID 11948245. 
  3. ^ Coyle, Joseph E; Qamar Seema; Rajashankar Kanagalaghatta R; Nikolov Dimitar B (January 2002). "Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding". Neuron (United States) 33 (1): 63–74. doi:10.1016/S0896-6273(01)00558-X. ISSN 0896-6273. PMID 11779472. 
  4. ^ Wang, H; Bedford F K; Brandon N J; Moss S J; Olsen R W (January 1999). "GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton". Nature (ENGLAND) 397 (6714): 69–72. doi:10.1038/16264. ISSN 0028-0836. PMID 9892355. 
  5. ^ Liu, F; Wan Q; Pristupa Z B; Yu X M; Wang Y T; Niznik H B (January 2000). "Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors". Nature (ENGLAND) 403 (6767): 274–80. doi:10.1038/35002014. ISSN 0028-0836. PMID 10659839. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.