GABRG2

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GABRG2
Identifiers
Aliases GABRG2, CAE2, ECA2, GEFSP3, gamma-aminobutyric acid type A receptor gamma2 subunit
External IDs MGI: 95623 HomoloGene: 22443 GeneCards: GABRG2
Targeted by Drug
picrotoxin[1]
RNA expression pattern
PBB GE GABRG2 206849 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198904
NM_000816
NM_198903

NM_008073
NM_177408

RefSeq (protein)

NP_000807
NP_944493
NP_944494

NP_032099.1
NP_803127.3
NP_032099
NP_803127

Location (UCSC) Chr 5: 162.07 – 162.16 Mb Chr 11: 41.91 – 42 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Gamma-aminobutyric acid receptor subunit gamma-2 is a protein that in humans is encoded by the GABRG2 gene.

Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates neuronal inhibition by binding to GABA receptors. The type A GABA receptors are pentameric chloride channels assembled from among many genetic variants of GABA(A) subunits. This gene encodes the gamma 2 subunit of GABA(A) receptor. Mutations in this gene have been associated with epilepsy and febrile seizures. Alternative splicing of this gene results in transcript variants encoding different isoforms.[4]

Interactions[edit]

GABRG2 has been shown to interact with GABARAP[5][6][7] and Dopamine receptor D5.[8]

See also[edit]

References[edit]

  1. ^ "Drugs that physically interact with Gamma-aminobutyric acid type A receptor gamma2 subunit view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ "Entrez Gene: GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2". 
  5. ^ Nymann-Andersen, Jesper; Wang Hongbing; Chen Li; Kittler Josef T; Moss Stephen J; Olsen Richard W (March 2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors". J. Neurochem. England. 80 (5): 815–23. doi:10.1046/j.0022-3042.2002.00762.x. ISSN 0022-3042. PMID 11948245. 
  6. ^ Coyle, Joseph E; Qamar Seema; Rajashankar Kanagalaghatta R; Nikolov Dimitar B (January 2002). "Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding". Neuron. United States. 33 (1): 63–74. doi:10.1016/S0896-6273(01)00558-X. ISSN 0896-6273. PMID 11779480. 
  7. ^ Wang, H; Bedford F K; Brandon N J; Moss S J; Olsen R W (January 1999). "GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton". Nature. ENGLAND. 397 (6714): 69–72. doi:10.1038/16264. ISSN 0028-0836. PMID 9892355. 
  8. ^ Liu, F; Wan Q; Pristupa Z B; Yu X M; Wang Y T; Niznik H B (January 2000). "Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors". Nature. ENGLAND. 403 (6767): 274–80. doi:10.1038/35002014. ISSN 0028-0836. PMID 10659839. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.