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Available structures
PDBOrtholog search: PDBe RCSB
AliasesGADD45GIP1, CKBBP2, CKbetaBP2, CRIF1, MRP-L59, PLINP, PLINP-1, PRG6, Plinp1, GADD45G interacting protein 1
External IDsMGI: 1914947 HomoloGene: 33474 GeneCards: GADD45GIP1
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for GADD45GIP1
Genomic location for GADD45GIP1
Band19p13.13Start12,953,119 bp[1]
End12,957,223 bp[1]
RNA expression pattern
PBB GE GADD45GIP1 212891 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 19: 12.95 – 12.96 MbChr 8: 84.83 – 84.84 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Growth arrest and DNA-damage-inducible proteins-interacting protein 1 is a protein that in humans is encoded by the GADD45GIP1 gene.[5][6][7]

GADD45GIP1, also known as CRIF1 is newly identified de novo components in large subunit of mitoribosome. It is essential for the translation of mitochondrial oxidative phosphorylation (OXPHOS) polypeptides in mammalian mitochondria. CRIF1 interacts with low-sulfur (LSU) proteins, some of which surround the exit tunnel of the mitoribosome, and also interacts with nascent OXPHOS polypeptides and the mitochondrial-specific chaperone Tid1. The essential role of CRIF1 in mitochondrial synthesis and membrane integration of OXPHOS polypeptides was shown in brain-specific CRIF1-deficient mice, which exhibited profound OXPHOS failure and marked neurodegeneration.[8]


GADD45GIP1 has been shown to interact with GADD45G,[9] GADD45B[9] and GADD45A.[9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179271 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033751 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Horikoshi N, Cong J, Kley N, Shenk T (Aug 1999). "Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene". Biochemical and Biophysical Research Communications. 261 (3): 864–9. doi:10.1006/bbrc.1999.1123. PMID 10441517.
  6. ^ Görnemann J, Hofmann TG, Will H, Müller M (Nov 2002). "Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins". Virology. 303 (1): 69–78. doi:10.1006/viro.2002.1670. PMID 12482659.
  7. ^ "Entrez Gene: GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1".
  8. ^ Kim, Soung Jung; Kwon, Min-chul; Ryu, Min Jeong; Chung, Hyo Kyun; Tadi, Surendar; Kim, Yong Kyung; et al. (2012). "CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane". Cell Metabolism. 16 (2): 274–283. doi:10.1016/j.cmet.2012.06.012. ISSN 1550-4131.
  9. ^ a b c Chung HK, Yi YW, Jung NC, Kim D, Suh JM, Kim H, Park KC, Song JH, Kim DW, Hwang ES, Yoon SH, Bae YS, Kim JM, Bae I, Shong M (Jul 2003). "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle". The Journal of Biological Chemistry. 278 (30): 28079–88. doi:10.1074/jbc.M212835200. PMID 12716909.

Further reading[edit]

  • Ahn BH, Kim TH, Bae YS (Oct 2001). "Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins". Molecules and Cells. 12 (2): 158–63. PMID 11710515.
  • Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Park KC, Song KH, Chung HK, Kim H, Kim DW, Song JH, Hwang ES, Jung HS, Park SH, Bae I, Lee IK, Choi HS, Shong M (Jan 2005). "CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation". Molecular Endocrinology. 19 (1): 12–24. doi:10.1210/me.2004-0107. PMID 15459248.
  • Oh NS, Yoon SH, Lee WK, Choi JY, Min do S, Bae YS (Jan 2007). "Phosphorylation of CKBBP2/CRIF1 by protein kinase CKII promotes cell proliferation". Gene. 386 (1–2): 147–53. doi:10.1016/j.gene.2006.08.023. PMID 17069992.
  • Nakayama K, Nakayama N, Wang TL, Shih Ie-M (Sep 2007). "NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor". Cancer Research. 67 (17): 8058–64. doi:10.1158/0008-5472.CAN-07-1357. PMID 17804717.