GADD45GIP1

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GADD45GIP1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GADD45GIP1, CKBBP2, CKbetaBP2, CRIF1, MRP-L59, PLINP, PLINP-1, PRG6, Plinp1, GADD45G interacting protein 1
External IDs MGI: 1914947 HomoloGene: 33474 GeneCards: GADD45GIP1
RNA expression pattern
PBB GE GADD45GIP1 212891 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_052850

NM_183358

RefSeq (protein)

NP_443082

NP_899202.3
NP_899202

Location (UCSC) Chr 19: 12.95 – 12.96 Mb Chr 8: 84.83 – 84.84 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Growth arrest and DNA-damage-inducible proteins-interacting protein 1 is a protein that in humans is encoded by the GADD45GIP1 gene.[3][4][5]

GADD45GIP1, also known as CRIF1 is newly identified de novo components in large subunit of mitoribosome. It is essential for the translation of mitochondrial oxidative phosphorylation polypeptides in mammalian mitochondria. CRIF1 interacts with LSU proteins, some of which surround the exit tunnel of the mitoribosome, and also interacts with nascent OXPHOS polypeptides and the mitochondrial-specific chaperone Tid1. The essential role of CRIF1 in mitochondrial synthesis and membrane integration of OXPHOS polypeptides was shown in brain-specific Crif1-deficient mice, which exhibited profound OXPHOS failure and marked neurodegeneration.[citation needed]

Interactions[edit]

GADD45GIP1 has been shown to interact with GADD45G,[6] GADD45B[6] and GADD45A.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Horikoshi N, Cong J, Kley N, Shenk T (Aug 1999). "Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene". Biochemical and Biophysical Research Communications. 261 (3): 864–9. doi:10.1006/bbrc.1999.1123. PMID 10441517. 
  4. ^ Görnemann J, Hofmann TG, Will H, Müller M (Nov 2002). "Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins". Virology. 303 (1): 69–78. doi:10.1006/viro.2002.1670. PMID 12482659. 
  5. ^ "Entrez Gene: GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1". 
  6. ^ a b c Chung HK, Yi YW, Jung NC, Kim D, Suh JM, Kim H, Park KC, Song JH, Kim DW, Hwang ES, Yoon SH, Bae YS, Kim JM, Bae I, Shong M (Jul 2003). "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle". The Journal of Biological Chemistry. 278 (30): 28079–88. doi:10.1074/jbc.M212835200. PMID 12716909. 

Further reading[edit]

  • Ahn BH, Kim TH, Bae YS (Oct 2001). "Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins". Molecules and Cells. 12 (2): 158–63. PMID 11710515. 
  • Chung HK, Yi YW, Jung NC, Kim D, Suh JM, Kim H, Park KC, Song JH, Kim DW, Hwang ES, Yoon SH, Bae YS, Kim JM, Bae I, Shong M (Jul 2003). "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle". The Journal of Biological Chemistry. 278 (30): 28079–88. doi:10.1074/jbc.M212835200. PMID 12716909. 
  • Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147Freely accessible. PMID 15231747. 
  • Park KC, Song KH, Chung HK, Kim H, Kim DW, Song JH, Hwang ES, Jung HS, Park SH, Bae I, Lee IK, Choi HS, Shong M (Jan 2005). "CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation". Molecular Endocrinology. 19 (1): 12–24. doi:10.1210/me.2004-0107. PMID 15459248. 
  • Oh NS, Yoon SH, Lee WK, Choi JY, Min do S, Bae YS (Jan 2007). "Phosphorylation of CKBBP2/CRIF1 by protein kinase CKII promotes cell proliferation". Gene. 386 (1-2): 147–53. doi:10.1016/j.gene.2006.08.023. PMID 17069992. 
  • Nakayama K, Nakayama N, Wang TL, Shih Ie-M (Sep 2007). "NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor". Cancer Research. 67 (17): 8058–64. doi:10.1158/0008-5472.CAN-07-1357. PMID 17804717.