GALNT14

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GALNT14
Identifiers
Aliases GALNT14, GALNT15, GalNac-T10, GalNac-T14, polypeptide N-acetylgalactosaminyltransferase 14
External IDs MGI: 1918935 HomoloGene: 56997 GeneCards: GALNT14
Genetically Related Diseases
human immunodeficiency virus infectious disease[1]
RNA expression pattern
PBB GE GALNT14 219271 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_027864

RefSeq (protein)

NP_082140.2
NP_082140

Location (UCSC) Chr 2: 30.91 – 31.16 Mb Chr 17: 73.49 – 73.71 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Polypeptide N-acetylgalactosaminyltransferase 14 is an enzyme that in humans is encoded by the GALNT14 gene.[4][5]

GALNT14 (EC 2.4.1.41) belongs to a large subfamily of glycosyltransferases residing in the Golgi apparatus. GALNT enzymes catalyze the first step in the O-glycosylation of mammalian proteins by transferring N-acetyl-D-galactosamine (GalNAc) to peptide substrates.[supplied by OMIM][5]

SNPs on GALNT14 have been shown to be associated to the chemotherapy responses of patients with advanced hepatocellular carcinoma.[6][7][8][9]

References[edit]

  1. ^ "Diseases that are genetically associated with GALNT14 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Wang H, Tachibana K, Zhang Y, Iwasaki H, Kameyama A, Cheng L, Guo J, Hiruma T, Togayachi A, Kudo T, Kikuchi N, Narimatsu H (Dec 2002). "Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14". Biochem Biophys Res Commun. 300 (3): 738–44. doi:10.1016/S0006-291X(02)02908-X. PMID 12507512. 
  5. ^ a b "Entrez Gene: GALNT14 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)". 
  6. ^ Liang KH, Lin CC, Yeh CT (Jul 2011). "GALNT14 SNP as a potential predictor of response to combination chemotherapy using 5-FU, mitoxantrone and cisplatin in advanced HCC.". Pharmacogenomics. 12: 1061–73. doi:10.2217/pgs.11.43. PMID 21635146. 
  7. ^ Yeh CT, Liang KH, Lin CC, Chang ML, Hsu CL, Hung CF (Mar 2014). "A single nucleotide polymorphism on the GALNT14 gene as an effective predictor of response to chemotherapy in advanced hepatocellular carcinoma.". Int J Cancer. 134: 1214–1224. doi:10.1002/ijc.28439. PMID 23959947. 
  8. ^ Liang KH, Yang PC, Yeh CT (Nov 2014). "Genotyping the GALNT14 gene by joint analysis of two linked single nucleotide polymorphisms using liver tissues for clinical and geographical comparisons.". Oncol Lett. 8: 2215–2220. doi:10.3892/ol.2014.2507. PMID 25295111. 
  9. ^ Lin WR, Hsu CW, Chen YC, Chang ML, Liang KH, Huang YH, Yeh CT (Jul 2014). "GALNT14 genotype, α-fetoprotein and therapeutic side effects predict post-chemotherapy survival in patients with advanced hepatocellular carcinoma.". Mol Clin Oncol. 2: 630–640. doi:10.3892/mco.2014.294. PMID 24940508. 

Further reading[edit]