Polypeptide N-acetylgalactosaminyltransferase 14 is an enzyme that in humans is encoded by the GALNT14gene.
GALNT14 (EC 18.104.22.168) belongs to a large subfamily of glycosyltransferases residing in the Golgi apparatus. GALNT enzymes catalyze the first step in the O-glycosylation of mammalian proteins by transferring N-acetyl-D-galactosamine (GalNAc) to peptide substrates.[supplied by OMIM]
SNPs on GALNT14 have been shown to be associated to the chemotherapy responses of patients with advanced hepatocellular carcinoma.
^Wang H, Tachibana K, Zhang Y, Iwasaki H, Kameyama A, Cheng L, Guo J, Hiruma T, Togayachi A, Kudo T, Kikuchi N, Narimatsu H (Dec 2002). "Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14". Biochem Biophys Res Commun. 300 (3): 738–44. doi:10.1016/S0006-291X(02)02908-X. PMID12507512.
^Liang KH, Lin CC, Yeh CT (Jul 2011). "GALNT14 SNP as a potential predictor of response to combination chemotherapy using 5-FU, mitoxantrone and cisplatin in advanced HCC.". Pharmacogenomics. 12: 1061–73. doi:10.2217/pgs.11.43. PMID21635146.
^Yeh CT, Liang KH, Lin CC, Chang ML, Hsu CL, Hung CF (Mar 2014). "A single nucleotide polymorphism on the GALNT14 gene as an effective predictor of response to chemotherapy in advanced hepatocellular carcinoma.". Int J Cancer. 134: 1214–1224. doi:10.1002/ijc.28439. PMID23959947.
^Liang KH, Yang PC, Yeh CT (Nov 2014). "Genotyping the GALNT14 gene by joint analysis of two linked single nucleotide polymorphisms using liver tissues for clinical and geographical comparisons.". Oncol Lett. 8: 2215–2220. doi:10.3892/ol.2014.2507. PMID25295111.
^Lin WR, Hsu CW, Chen YC, Chang ML, Liang KH, Huang YH, Yeh CT (Jul 2014). "GALNT14 genotype, α-fetoprotein and therapeutic side effects predict post-chemotherapy survival in patients with advanced hepatocellular carcinoma.". Mol Clin Oncol. 2: 630–640. doi:10.3892/mco.2014.294. PMID24940508.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.