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Glucosidase, alpha; neutral AB
External IDs OMIM104160 MGI1097667 HomoloGene5426 ChEMBL: 2519 GeneCards: GANAB Gene
EC number
RNA expression pattern
PBB GE GANAB 211934 x at tn.png
PBB GE GANAB 214626 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23193 14376
Ensembl ENSG00000089597 ENSMUSG00000071650
UniProt Q14697 Q8BHN3
RefSeq (mRNA) NM_001278192 NM_001293621
RefSeq (protein) NP_001265121 NP_001280550
Location (UCSC) Chr 11:
62.62 – 62.65 Mb
Chr 19:
8.9 – 8.92 Mb
PubMed search [1] [2]

Neutral alpha-glucosidase AB is an enzyme that in humans is encoded by the GANAB gene.[1][2][3]


GANAB has been shown to interact with PTPRC.[4][5][6]


  1. ^ Treml K, Meimaroglou D, Hentges A, Bause E (May 2000). "The alpha- and beta-subunits are required for expression of catalytic activity in the hetero-dimeric glucosidase II complex from human liver". Glycobiology 10 (5): 493–502. doi:10.1093/glycob/10.5.493. PMID 10764838. 
  2. ^ Martiniuk F, Smith M, Ellenbogen A, Desnick RJ, Astrin K, Mitra J, Hirschhorn R (July 1983). "Assignment of the gene for neutral alpha-glucosidase AB to chromosome 11". Cytogenet Cell Genet 35 (2): 110–6. doi:10.1159/000131851. PMID 6342981. 
  3. ^ "Entrez Gene: GANAB glucosidase, alpha; neutral AB". 
  4. ^ Arendt CW, Ostergaard HL (May 1997). "Identification of the CD45-associated 116-kDa and 80-kDa proteins as the alpha- and beta-subunits of alpha-glucosidase II". J. Biol. Chem. 272 (20): 13117–25. doi:10.1074/jbc.272.20.13117. PMID 9148925. 
  5. ^ Baldwin TA, Gogela-Spehar M, Ostergaard HL (October 2000). "Specific isoforms of the resident endoplasmic reticulum protein glucosidase II associate with the CD45 protein-tyrosine phosphatase via a lectin-like interaction". J. Biol. Chem. 275 (41): 32071–6. doi:10.1074/jbc.M003088200. PMID 10921916. 
  6. ^ Baldwin TA, Ostergaard HL (October 2001). "Developmentally regulated changes in glucosidase II association with, and carbohydrate content of, the protein tyrosine phosphatase CD45". J. Immunol. 167 (7): 3829–35. doi:10.4049/jimmunol.167.7.3829. PMID 11564800. 

Further reading[edit]