GANC

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GANC
Identifiers
Aliases GANC
External IDs MGI: 1923301 HomoloGene: 25627 GeneCards: 2595
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198141
NM_001301409
NM_001301410

NM_172672

RefSeq (protein)

NP_937784.2

NP_766260.2

Location (UCSC) Chr 15: 42.27 – 42.36 Mb Chr 2: 120.4 – 120.46 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Neutral alpha-glucosidase C is an enzyme that in humans is encoded by the GANC gene.[1][2][3]

Function[edit]

Glycoside hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. This gene encodes a member of glycosyl hydrolases family 31. This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. This is a key enzyme in glycogen metabolism and its gene localizes to a chromosomal region (15q15) that is associated with susceptibility to diabetes.[3]

References[edit]

  1. ^ Martiniuk F, Hirschhorn R, Smith M (Oct 1980). "Assignment of the gene for human neutral alpha-glucosidase C to chromosome 15". Cytogenetics and Cell Genetics 27 (2-3): 168–75. doi:10.1159/000131478. PMID 6995030. 
  2. ^ Hirschhorn R, Huie ML, Kasper JS (Oct 2002). "Computer assisted cloning of human neutral alpha-glucosidase C (GANC): a new paralog in the glycosyl hydrolase gene family 31". Proceedings of the National Academy of Sciences of the United States of America 99 (21): 13642–6. doi:10.1073/pnas.202383599. PMC 129728. PMID 12370436. 
  3. ^ a b "Entrez Gene: GANC glucosidase, alpha; neutral C". 

Further reading[edit]