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Glucosidase, alpha; neutral C
Symbols GANC ; FLJ40082; MGC138256
External IDs OMIM104180 HomoloGene25627 ChEMBL: 2520 GeneCards: GANC Gene
EC number
Species Human Mouse
Entrez 2595 76051
Ensembl ENSG00000214013 ENSMUSG00000062646
UniProt Q8TET4 Q8BVW0
RefSeq (mRNA) NM_198141 NM_172672
RefSeq (protein) NP_937784 NP_766260
Location (UCSC) Chr 15:
42.57 – 42.65 Mb
Chr 2:
120.4 – 120.46 Mb
PubMed search [1] [2]

Neutral alpha-glucosidase C is an enzyme that in humans is encoded by the GANC gene.[1][2][3]


Glycoside hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. This gene encodes a member of glycosyl hydrolases family 31. This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. This is a key enzyme in glycogen metabolism and its gene localizes to a chromosomal region (15q15) that is associated with susceptibility to diabetes.[3]


  1. ^ Martiniuk F, Hirschhorn R, Smith M (Oct 1980). "Assignment of the gene for human neutral alpha-glucosidase C to chromosome 15". Cytogenetics and Cell Genetics 27 (2-3): 168–75. doi:10.1159/000131478. PMID 6995030. 
  2. ^ Hirschhorn R, Huie ML, Kasper JS (Oct 2002). "Computer assisted cloning of human neutral alpha-glucosidase C (GANC): a new paralog in the glycosyl hydrolase gene family 31". Proceedings of the National Academy of Sciences of the United States of America 99 (21): 13642–6. doi:10.1073/pnas.202383599. PMC 129728. PMID 12370436. 
  3. ^ a b "Entrez Gene: GANC glucosidase, alpha; neutral C". 

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