GBA2

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GBA2
Identifiers
Aliases GBA2, SPG46, AD035, NLGase, glucosylceramidase beta 2
External IDs MGI: 2654325 HomoloGene: 10859 GeneCards: 57704
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020944

NM_172692

RefSeq (protein)

NP_065995.1

NP_766280.2

Location (UCSC) Chr 9: 35.74 – 35.75 Mb Chr 4: 43.57 – 43.58 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Non-lysosomal glucosylceramidase is an enzyme that in humans is encoded by the GBA2 gene.[1][2] It has glucosylceramidase (EC 3.2.1.45) activity.

Function[edit]

This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism.[2]

See also[edit]

References[edit]

  1. ^ Matern H, Boermans H, Lottspeich F, Matern S (Oct 2001). "Molecular cloning and expression of human bile acid beta-glucosidase". J Biol Chem 276 (41): 37929–33. doi:10.1074/jbc.M104290200. PMID 11489889. 
  2. ^ a b "Entrez Gene: GBA2 glucosidase, beta (bile acid) 2". 

Further reading[edit]