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Guanylate binding protein 1, interferon-inducible
Protein GBP1 PDB 1dg3.png
PDB rendering based on 1dg3.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol GBP1
External IDs OMIM600411 HomoloGene133759 GeneCards: GBP1 Gene
RNA expression pattern
PBB GE GBP1 202270 at tn.png
PBB GE GBP1 202269 x at tn.png
More reference expression data
Species Human Mouse
Entrez 2633 n/a
Ensembl ENSG00000117228 n/a
UniProt P32455 n/a
RefSeq (mRNA) NM_002053 n/a
RefSeq (protein) NP_002044 n/a
Location (UCSC) Chr 1:
89.05 – 89.07 Mb
PubMed search [1] n/a

Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1 gene.[1][2] It belongs to the dynamin superfamily of large GTPases.[3]


Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.[2]


  1. ^ Strehlow I, Lohmann-Matthes ML, Decker T (Aug 1994). "The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1". Gene 144 (2): 295–9. doi:10.1016/0378-1119(94)90393-X. PMID 7518790. 
  2. ^ a b "Entrez Gene: GBP1 guanylate binding protein 1, interferon-inducible, 67kDa". 
  3. ^ Praefcke GJ, McMahon HT (February 2004). "The dynamin superfamily: universal membrane tubulation and fission molecules?". Nat. Rev. Mol. Cell Biol. 5 (2): 133–47. doi:10.1038/nrm1313. PMID 15040446. 

Further reading[edit]