GBP1

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GBP1
Protein GBP1 PDB 1dg3.png
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesGBP1, guanylate binding protein 1
External IDsHomoloGene: 133759 GeneCards: GBP1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for GBP1
Genomic location for GBP1
Band1p22.2Start89,052,319 bp[1]
End89,065,360 bp[1]
RNA expression pattern
PBB GE GBP1 202270 at fs.png

PBB GE GBP1 202269 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002053

n/a

RefSeq (protein)

NP_002044

n/a

Location (UCSC)Chr 1: 89.05 – 89.07 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1 gene.[3][4] It belongs to the dynamin superfamily of large GTPases.[5]

Function[edit]

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.[4]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117228 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Strehlow I, Lohmann-Matthes ML, Decker T (Aug 1994). "The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1". Gene. 144 (2): 295–9. doi:10.1016/0378-1119(94)90393-X. PMID 7518790. 
  4. ^ a b "Entrez Gene: GBP1 guanylate binding protein 1, interferon-inducible, 67kDa". 
  5. ^ Praefcke GJ, McMahon HT (February 2004). "The dynamin superfamily: universal membrane tubulation and fission molecules?". Nat. Rev. Mol. Cell Biol. 5 (2): 133–47. doi:10.1038/nrm1313. PMID 15040446. 

Further reading[edit]