GBP1

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GBP1
Protein GBP1 PDB 1dg3.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases GBP1
External IDs HomoloGene: 133759 GeneCards: 2633
RNA expression pattern
PBB GE GBP1 202269 x at tn.png

PBB GE GBP1 202270 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002053

n/a

RefSeq (protein)

NP_002044.2

n/a

Location (UCSC) Chr 1: 89.05 – 89.07 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1 gene.[2][3] It belongs to the dynamin superfamily of large GTPases.[4]

Function[edit]

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Strehlow I, Lohmann-Matthes ML, Decker T (Aug 1994). "The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1". Gene. 144 (2): 295–9. doi:10.1016/0378-1119(94)90393-X. PMID 7518790. 
  3. ^ a b "Entrez Gene: GBP1 guanylate binding protein 1, interferon-inducible, 67kDa". 
  4. ^ Praefcke GJ, McMahon HT (February 2004). "The dynamin superfamily: universal membrane tubulation and fission molecules?". Nat. Rev. Mol. Cell Biol. 5 (2): 133–47. doi:10.1038/nrm1313. PMID 15040446. 

Further reading[edit]