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Aliases GCC1, GCC1P, GCC88, GRIP and coiled-coil domain containing 1
External IDs MGI: 1921625 HomoloGene: 11567 GeneCards: GCC1
Gene location (Human)
Chromosome 7 (human)
Chr. Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for GCC1
Genomic location for GCC1
Band 7q32.1 Start 127,580,618 bp[1]
End 127,593,611 bp[1]
RNA expression pattern
PBB GE GCC1 218912 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 7: 127.58 – 127.59 Mb Chr 7: 28.42 – 28.43 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

GRIP and coiled-coil domain-containing protein 1 is a protein that in humans is encoded by the GCC1 gene.[5][6]


The protein encoded by this gene is a peripheral membrane protein. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompartment involved with membrane transport.[6]


GCC1 has been shown to interact with TRIM29.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179562 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029708 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kjer-Nielsen L, Teasdale RD, van Vliet C, Gleeson PA (May 1999). "A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins". Curr. Biol. 9 (7): 385–8. doi:10.1016/S0960-9822(99)80168-7. PMID 10209125. 
  6. ^ a b "Entrez Gene: GCC1 GRIP and coiled-coil domain containing 1". 
  7. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]