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Protein GCHFR PDB 1is7.png
Aliases GCHFR, GFRP, HsT16933, P35, GTP cyclohydrolase I feedback regulator
External IDs MGI: 2443977 HomoloGene: 3849 GeneCards: GCHFR
Gene location (Human)
Chromosome 15 (human)
Chr. Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for GCHFR
Genomic location for GCHFR
Band 15q15.1 Start 40,764,020 bp[1]
End 40,767,710 bp[1]
RNA expression pattern
PBB GE GCHFR 204867 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 15: 40.76 – 40.77 Mb Chr 2: 119.17 – 119.17 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

GTP cyclohydrolase 1 feedback regulatory protein is an enzyme that in humans is encoded by the GCHFR gene.[5][6][7]

GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137880 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046814 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Milstien S, Jaffe H, Kowlessur D, Bonner TI (Oct 1996). "Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP". J. Biol. Chem. 271 (33): 19743–51. doi:10.1074/jbc.271.33.19743. PMID 8702680. 
  6. ^ Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R, et al. (Mar 1993). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669. 
  7. ^ a b "Entrez Gene: GCHFR GTP cyclohydrolase I feedback regulator". 

Further reading[edit]