GCLM

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For the post-nomial, see Legion of Merit (Rhodesia).
GCLM
Identifiers
Aliases GCLM, GLCLR, glutamate-cysteine ligase modifier subunit
External IDs MGI: 104995 HomoloGene: 1557 GeneCards: GCLM
RNA expression pattern
PBB GE GCLM 203925 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308253
NM_002061

NM_008129

RefSeq (protein)

NP_001295182
NP_002052

NP_032155.1
NP_032155

Location (UCSC) Chr 1: 93.89 – 93.91 Mb Chr 3: 122.25 – 122.27 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Glutamate-cysteine ligase regulatory subunit is an enzyme that in humans is encoded by the GCLM gene.[3][4]

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subuit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Gipp JJ, Bailey HH, Mulcahy RT (Feb 1995). "Cloning and sequencing of the cDNA for the light subunit of human liver gamma-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues". Biochem Biophys Res Commun. 206 (2): 584–9. doi:10.1006/bbrc.1995.1083. PMID 7826375. 
  4. ^ a b "Entrez Gene: GCLM glutamate-cysteine ligase, modifier subunit". 

Further reading[edit]