GCM1

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GCM1
Protein GCM1 PDB 1odh.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGCM1, GCMA, hGCMa, glial cells missing homolog 1, glial cells missing transcription factor 1
External IDsOMIM: 603715 MGI: 108045 HomoloGene: 2702 GeneCards: GCM1
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for GCM1
Genomic location for GCM1
Band6p12.1Start53,126,961 bp[1]
End53,148,841 bp[1]
RNA expression pattern
PBB GE GCM1 206269 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003643

NM_008103

RefSeq (protein)

NP_003634

NP_032129

Location (UCSC)Chr 6: 53.13 – 53.15 MbChr 9: 78.05 – 78.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chorion-specific transcription factor GCMa is a protein that, in humans, is encoded by the GCM1 gene.[5][6]

This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137270 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023333 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Akiyama Y, Hosoya T, Poole AM, Hotta Y (Jan 1997). "The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals". Proc Natl Acad Sci U S A. 93 (25): 14912–6. doi:10.1073/pnas.93.25.14912. PMC 26236. PMID 8962155.
  6. ^ a b "Entrez Gene: GCM1 glial cells missing homolog 1 (Drosophila)".

Further reading[edit]