GC box

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In molecular biology, a GC box is a distinct pattern of nucleotides found in the promoter region of some eukaryotic genes upstream of the TATA box and approximately 110 bases upstream from the transcription initiation site. It has a consensus sequence GGGCGG which is position dependent and orientation independent. The GC elements are bound by transcription factors and have similar functions to enhancers.[1]


  1. ^ Klug WS, Cummings MR, Spencer CA, Palladina MA (2009). Concepts of Genetics (Ninth ed.). San Francisco: Pearson Benjamin Cummings. pp. 463–464. ISBN 978-0-321-54098-0.