From Wikipedia, the free encyclopedia
Jump to: navigation, search
Aliases GDF10, BMP-3b, BMP3B, growth differentiation factor 10
External IDs OMIM: 601361 MGI: 95684 HomoloGene: 3640 GeneCards: 2662
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 10: 47.3 – 47.31 Mb Chr 14: 33.92 – 33.94 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Growth differentiation factor 10 (GDF10) also known as bone morphogenetic protein 3B (BMP-3B) is a protein that in humans is encoded by the GDF10 gene.[3]

GDF10 belongs to the transforming growth factor beta superfamily that is closely related to bone morphogenetic protein-3 (BMP3). It plays a role in head formation and may have multiple roles in skeletal morphogenesis.[3][4] GDF10 is also known as BMP-3b, with GDF10 and BMP3 regarded as a separate subgroup within the TGF-beta superfamily.[3]

In mice, GDF10 mRNA is abundant in the brain, inner ear, uterus, prostate, neural tissues, blood vessels and adipose tissue with low expression in spleen and liver. It is also present in bone of both adults and neonatal mice.[3] Human GDF10 mRNA is found in the cochlea and lung of foetuses, and in testis, retina, pineal gland, and other neural tissues of adults.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b c d Cunningham NS, Jenkins NA, Gilbert DJ, Copeland NG, Reddi AH, Lee SJ (1995). "Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3". Growth Factors. 12 (2): 99–109. doi:10.3109/08977199509028956. PMID 8679252. 
  4. ^ Hino J, Kangawa K, Matsuo H, Nohno T, Nishimatsu S (2004). "Bone morphogenetic protein-3 family members and their biological functions". Front Biosci. 9: 1520–9. doi:10.2741/1355. PMID 14977563. 
  5. ^ Katoh Y, Katoh M (2006). "Comparative integromics on BMP/GDF family". Int J Mol Med. 17 (5): 951–5. doi:10.3892/ijmm.17.5.951. PMID 16596286. 

Further reading[edit]