GDF15

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GDF15
Identifiers
Aliases GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB, growth differentiation factor 15
External IDs OMIM: 605312 MGI: 1346047 HomoloGene: 3576 GeneCards: GDF15
RNA expression pattern
PBB GE GDF15 221577 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004864

NM_011819
NM_001330687

RefSeq (protein)

NP_004855

NP_001317616
NP_035949

Location (UCSC) Chr 19: 18.37 – 18.39 Mb Chr 8: 70.63 – 70.63 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Growth/differentiation factor 15 (GDF15) was first identified as Macrophage inhibitory cytokine-1 or MIC-1.[3] It is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes.[4] GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB.[5] GDF15 mRNA is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung.[4][5][6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Bootcov, Michelle R; Bauskin, Asne R.; et al. (1997). "MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily". PNAS. 94 (21): 11514-11519. 
  4. ^ a b Zimmers T, Jin X, Hsiao E, McGrath S, Esquela A, Koniaris L (2005). "Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury". Shock. 23 (6): 543–8. PMID 15897808. 
  5. ^ a b Hsiao E, Koniaris L, Zimmers-Koniaris T, Sebald S, Huynh T, Lee S (2000). "Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury". Mol Cell Biol. 20 (10): 3742–3751. PMC 85678Freely accessible. PMID 10779363. doi:10.1128/MCB.20.10.3742-3751.2000. 
  6. ^ Ago T, Sadoshima J (2006). "GDF15, a cardioprotective TGF-beta superfamily protein". Circ Res. 98 (3): 294–297. PMID 16484622. doi:10.1161/01.RES.0000207919.83894.9d. 

External links[edit]