GDF15

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GDF15
Identifiers
Aliases GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB, growth differentiation factor 15
External IDs OMIM: 605312 MGI: 1346047 HomoloGene: 3576 GeneCards: 9518
RNA expression pattern
PBB GE GDF15 221577 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004864

NM_011819

RefSeq (protein)

NP_004855.2

NP_035949.2

Location (UCSC) Chr 19: 18.37 – 18.39 Mb Chr 8: 70.63 – 70.63 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Growth differentiation factor 15 (GDF15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes.[1] GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB.[2] GDF15 mRNA is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung.[1][2][3]

References[edit]

  1. ^ a b Zimmers T, Jin X, Hsiao E, McGrath S, Esquela A, Koniaris L (2005). "Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury". Shock 23 (6): 543–8. PMID 15897808. 
  2. ^ a b Hsiao E, Koniaris L, Zimmers-Koniaris T, Sebald S, Huynh T, Lee S (2000). "Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury". Mol Cell Biol 20 (10): 3742–3751. doi:10.1128/MCB.20.10.3742-3751.2000. PMC 85678. PMID 10779363. 
  3. ^ Ago T, Sadoshima J (2006). "GDF15, a cardioprotective TGF-beta superfamily protein". Circ Res 98 (3): 294–297. doi:10.1161/01.RES.0000207919.83894.9d. PMID 16484622. 

External links[edit]