GDP-fucose protein O-fucosyltransferase 2

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protein O-fucosyltransferase 2
Symbol POFUT2
Alt. symbols C21orf80
Entrez 23275
HUGO 14683
OMIM 610249
RefSeq NM_133634
UniProt Q9Y2G5
Other data
Locus Chr. 21 q22.3

GDP-fucose protein O-fucosyltransferase 2 (POFUT2) is an enzyme responsible for adding fucose sugars in O linkage to serine or threonine residues in Thrombospondin repeats.[1] The protein is an inverting glycosyltransferase, which means that the enzyme uses GDP-β-L-fucose as a donor substrate and transfers the fucose in O linkage to the protein producing fucose-α-O-serine/threonine.

Almost all glycosyltransferases reside in the Golgi apparatus. However, POFUT2 as well as the related enzyme POFUT1 have recently been shown to reside in the endoplasmic reticulum.


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