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Gem (nuclear organelle) associated protein 4
Symbols GEMIN4 ; HC56; HCAP1; HHRF-1; p97
External IDs OMIM606969 MGI2449313 HomoloGene69193 GeneCards: GEMIN4 Gene
RNA expression pattern
PBB GE GEMIN4 217099 s at tn.png
PBB GE GEMIN4 205527 s at tn.png
More reference expression data
Species Human Mouse
Entrez 50628 276919
Ensembl ENSG00000179409 ENSMUSG00000049396
UniProt P57678 E9Q6V6
RefSeq (mRNA) NM_015721 NM_177367
RefSeq (protein) NP_056536 NP_796341
Location (UCSC) Chr 17:
0.74 – 0.75 Mb
Chr 11:
76.21 – 76.22 Mb
PubMed search [1] [2]

Component of gems 4 is a protein that in humans is encoded by the GEMIN4 gene.[1][2]


The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[2]


GEMIN4 has been shown to interact with:


  1. ^ a b Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (April 2000). "Gemin4: A Novel Component of the Smn Complex That Is Found in Both Gems and Nucleoli". J Cell Biol 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331. 
  2. ^ a b "Entrez Gene: GEMIN4 gem (nuclear organelle) associated protein 4". 
  3. ^ a b Carnegie GK, Sleeman JE, Morrice N, Hastie CJ, Peggie MW, Philp A, Lamond AI, Cohen PT (May 2003). "Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs". J. Cell. Sci. 116 (Pt 10): 1905–13. doi:10.1242/jcs.00409. PMID 12668731. 
  4. ^ a b Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (March 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMC 155365. PMID 11914277. 
  5. ^ Nelson PT, Hatzigeorgiou AG, Mourelatos Z (March 2004). "miRNP:mRNA association in polyribosomes in a human neuronal cell line". RNA 10 (3): 387–94. doi:10.1261/rna.5181104. PMC 1370934. PMID 14970384. 
  6. ^ Park JW, Voss PG, Grabski S, Wang JL, Patterson RJ (September 2001). "Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein". Nucleic Acids Res. 29 (17): 3595–602. doi:10.1093/nar/29.17.3595. PMC 55878. PMID 11522829. 
  7. ^ Meister G, Bühler D, Laggerbauer B, Zobawa M, Lottspeich F, Fischer U (August 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. 9 (13): 1977–86. doi:10.1093/hmg/9.13.1977. PMID 10942426. 

Further reading[edit]