Gem-associated protein 4

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GEMIN4
Identifiers
Aliases GEMIN4, HC56, HCAP1, HHRF-1, p97, gem nuclear organelle associated protein 4
External IDs MGI: 2449313 HomoloGene: 69193 GeneCards: GEMIN4
RNA expression pattern
PBB GE GEMIN4 217099 s at fs.png

PBB GE GEMIN4 205527 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015721

NM_177367

RefSeq (protein)

NP_056536

n/a

Location (UCSC) Chr 17: 0.74 – 0.75 Mb Chr 11: 76.21 – 76.22 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Gem-associated protein 4 is a protein that in humans is encoded by the GEMIN4 gene.[3][4]

Function[edit]

The product of this gene is part of the SMN protein complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[4]

Interactions[edit]

GEMIN4 has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (April 2000). "Gemin4: A Novel Component of the Smn Complex That Is Found in Both Gems and Nucleoli". J Cell Biol. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312Freely accessible. PMID 10725331. 
  4. ^ a b "Entrez Gene: GEMIN4 gem (nuclear organelle) associated protein 4". 
  5. ^ a b Carnegie GK, Sleeman JE, Morrice N, Hastie CJ, Peggie MW, Philp A, Lamond AI, Cohen PT (May 2003). "Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs". J. Cell. Sci. 116 (Pt 10): 1905–13. doi:10.1242/jcs.00409. PMID 12668731. 
  6. ^ a b Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (March 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMC 155365Freely accessible. PMID 11914277. 
  7. ^ Nelson PT, Hatzigeorgiou AG, Mourelatos Z (March 2004). "miRNP:mRNA association in polyribosomes in a human neuronal cell line". RNA. 10 (3): 387–94. doi:10.1261/rna.5181104. PMC 1370934Freely accessible. PMID 14970384. 
  8. ^ Park JW, Voss PG, Grabski S, Wang JL, Patterson RJ (September 2001). "Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein". Nucleic Acids Res. 29 (17): 3595–602. doi:10.1093/nar/29.17.3595. PMC 55878Freely accessible. PMID 11522829. 
  9. ^ Meister G, Bühler D, Laggerbauer B, Zobawa M, Lottspeich F, Fischer U (August 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. 9 (13): 1977–86. doi:10.1093/hmg/9.13.1977. PMID 10942426. 

Further reading[edit]