Gem-associated protein 7

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Gem (nuclear organelle) associated protein 7
Protein GEMIN7 PDB 1y96.png
PDB rendering based on 1y96.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GEMIN7 ; SIP3
External IDs OMIM607419 MGI1916981 HomoloGene11668 GeneCards: GEMIN7 Gene
RNA expression pattern
PBB GE GEMIN7 219085 s at tn.png
More reference expression data
Species Human Mouse
Entrez 79760 69731
Ensembl ENSG00000142252 ENSMUSG00000044709
UniProt Q9H840 Q9CWY4
RefSeq (mRNA) NM_001007269 NM_027189
RefSeq (protein) NP_001007270 NP_081465
Location (UCSC) Chr 19:
45.08 – 45.09 Mb
Chr 7:
19.56 – 19.57 Mb
PubMed search [1] [2]

Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene.[1][2]

The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.[2]


Gem-associated protein 7 has been shown to interact with SMN1[1][3] and Gem-associated protein 6.[1][4]


  1. ^ a b c Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". J Biol Chem 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586. 
  2. ^ a b "Entrez Gene: GEMIN7 gem (nuclear organelle) associated protein 7". 
  3. ^ Pellizzoni, Livio; Baccon Jennifer; Rappsilber Juri; Mann Matthias; Dreyfuss Gideon (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". J. Biol. Chem. (United States) 277 (9): 7540–5. doi:10.1074/jbc.M110141200. ISSN 0021-9258. PMID 11748230. 
  4. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

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