GEM (gene)

From Wikipedia, the free encyclopedia
Jump to: navigation, search
GEM
Protein GEM PDB 2cjw.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GEM, KIR, GTP binding protein overexpressed in skeletal muscle
External IDs MGI: 99844 HomoloGene: 38024 GeneCards: GEM
RNA expression pattern
PBB GE GEM 204472 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_181702
NM_005261

NM_010276

RefSeq (protein)

NP_005252
NP_859053

NP_034406.2
NP_034406

Location (UCSC) Chr 8: 94.25 – 94.26 Mb Chr 4: 11.7 – 11.71 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

GTP-binding protein GEM is a protein that in humans is encoded by the GEM gene.[3][4][5]

The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Maguire J, Santoro T, Jensen P, Siebenlist U, Yewdell J, Kelly K (Aug 1994). "Gem: an induced, immediate early protein belonging to the Ras family". Science. 265 (5169): 241–4. doi:10.1126/science.7912851. PMID 7912851. 
  4. ^ Ward Y, Yap SF, Ravichandran V, Matsumura F, Ito M, Spinelli B, Kelly K (Apr 2002). "The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway". J Cell Biol. 157 (2): 291–302. doi:10.1083/jcb.200111026. PMC 2199248Freely accessible. PMID 11956230. 
  5. ^ a b "Entrez Gene: GEM GTP binding protein overexpressed in skeletal muscle". 

Further reading[edit]