GEM (gene)

GEM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CJW, 2G3Y, 2HT6
Identifiers
Aliases	GEM, KIR, GTP binding protein overexpressed in skeletal muscle
External IDs	OMIM: 600164; MGI: 99844; HomoloGene: 38024; GeneCards: GEM; OMA:GEM - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	94,262,350 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	11,714,752 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; gallbladder; ; tail of epididymis; ; vena cava; ; gastric mucosa; ; right coronary artery; ; ascending aorta; ; cartilage tissue; ; Descending thoracic aorta; ; mucosa of urinary bladder;
	Top expressed in
	ascending aorta; ; cumulus cell; ; aortic valve; ; skin of external ear; ; pineal gland; ; neural layer of retina; ; adrenal gland; ; endocardial cushion; ; spermatocyte; ; atrioventricular valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; magnesium ion binding; calmodulin binding; GDP binding; GTPase activity; calcium channel regulator activity;
Cellular component	spindle midzone; cytoplasmic side of plasma membrane; plasma membrane; midbody; mitotic spindle; nucleus; membrane;
Biological process	cell surface receptor signaling pathway; metaphase plate congression; chromosome organization; immune response; signal transduction; mitotic cell cycle; negative regulation of high voltage-gated calcium channel activity;
	Sources:Amigo / QuickGO
Orthologs
	2669
	14579
	ENSG00000164949
	ENSMUSG00000028214
	P55040
	P55041
	NM_181702; NM_005261
	NM_010276
	NP_005252; NP_859053
	NP_034406
	Wikidata
View/Edit Human	View/Edit Mouse

GTP-binding protein GEM is a protein that in humans is encoded by the GEM gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164949 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028214 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Maguire J, Santoro T, Jensen P, Siebenlist U, Yewdell J, Kelly K (Aug 1994). "Gem: an induced, immediate early protein belonging to the Ras family". Science. 265 (5169): 241–4. doi:10.1126/science.7912851. PMID 7912851.
^ Ward Y, Yap SF, Ravichandran V, Matsumura F, Ito M, Spinelli B, Kelly K (Apr 2002). "The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway". J Cell Biol. 157 (2): 291–302. doi:10.1083/jcb.200111026. PMC 2199248. PMID 11956230.
^ "Entrez Gene: GEM GTP binding protein overexpressed in skeletal muscle".

References

Further reading