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Growth factor independent 1 transcription repressor
Symbols GFI1 ; GFI-1; GFI1A; SCN2; ZNF163
External IDs OMIM600871 MGI103170 HomoloGene3854 GeneCards: GFI1 Gene
RNA expression pattern
PBB GE GFI1 206589 at tn.png
More reference expression data
Species Human Mouse
Entrez 2672 14581
Ensembl ENSG00000162676 ENSMUSG00000029275
UniProt Q99684 P70338
RefSeq (mRNA) NM_001127215 NM_001267621
RefSeq (protein) NP_001120687 NP_001254550
Location (UCSC) Chr 1:
92.47 – 92.49 Mb
Chr 5:
107.72 – 107.73 Mb
PubMed search [1] [2]

Zinc finger protein Gfi-1 is a protein that in humans is encoded by the GFI1 gene.[1][2]


GFI1 has been shown to interact with PIAS3[3] and RUNX1T1.[4]


  1. ^ Bell DW, Taguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Gilks CB, Zweidler-McKay P, Grimes HL, Tsichlis PN, Testa JR (July 1995). "Chromosomal localization of a gene, GF1, encoding a novel zinc finger protein reveals a new syntenic region between man and rodents". Cytogenet Cell Genet 70 (3–4): 263–7. doi:10.1159/000134048. PMID 7789186. 
  2. ^ "Entrez Gene: GFI1 growth factor independent 1". 
  3. ^ Rödel B, Tavassoli K, Karsunky H, Schmidt T, Bachmann M, Schaper F, Heinrich P, Shuai K, Elsässer HP, Möröy T (November 2000). "The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3". EMBO J. 19 (21): 5845–55. doi:10.1093/emboj/19.21.5845. PMC 305799. PMID 11060035. 
  4. ^ McGhee L, Bryan J, Elliott L, Grimes HL, Kazanjian A, Davis JN, Meyers S (August 2003). "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism". J. Cell. Biochem. 89 (5): 1005–18. doi:10.1002/jcb.10548. PMID 12874834. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.