GFI1

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GFI1
Identifiers
AliasesGFI1, GFI-1, GFI1A, SCN2, ZNF163, growth factor independent 1 transcriptional repressor
External IDsMGI: 103170 HomoloGene: 3854 GeneCards: GFI1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for GFI1
Genomic location for GFI1
Band1p22.1Start92,473,043 bp[1]
End92,486,925 bp[1]
RNA expression pattern
PBB GE GFI1 206589 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001127215
NM_001127216
NM_005263

NM_001267621
NM_010278

RefSeq (protein)

NP_001120687
NP_001120688
NP_005254

NP_001254550
NP_034408

Location (UCSC)Chr 1: 92.47 – 92.49 MbChr 5: 107.72 – 107.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein Gfi-1 is a transcriptional repressor that in humans is encoded by the GFI1 gene.[5] It is important normal hematopoiesis.[6]

Interactions[edit]

GFI1 has been shown to interact with PIAS3[7] and RUNX1T1.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162676 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029275 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Bell DW, Taguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Gilks CB, Zweidler-McKay P, Grimes HL, Tsichlis PN, Testa JR (July 1995). "Chromosomal localization of a gene, GF1, encoding a novel zinc finger protein reveals a new syntenic region between man and rodents". Cytogenet Cell Genet. 70 (3–4): 263–7. doi:10.1159/000134048. PMID 7789186.
  6. ^ "Entrez Gene: GFI1 growth factor independent 1".
  7. ^ Rödel B, Tavassoli K, Karsunky H, Schmidt T, Bachmann M, Schaper F, Heinrich P, Shuai K, Elsässer HP, Möröy T (November 2000). "The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3". EMBO J. 19 (21): 5845–55. doi:10.1093/emboj/19.21.5845. PMC 305799. PMID 11060035.
  8. ^ McGhee L, Bryan J, Elliott L, Grimes HL, Kazanjian A, Davis JN, Meyers S (August 2003). "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism". J. Cell. Biochem. 89 (5): 1005–18. doi:10.1002/jcb.10548. PMID 12874834.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.