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Protein GGA2 PDB 1mhq.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases GGA2, VEAR, golgi associated, gamma adaptin ear containing, ARF binding protein 2
External IDs MGI: 1921355 HomoloGene: 22860 GeneCards: GGA2
RNA expression pattern
PBB GE GGA2 208914 at fs.png

PBB GE GGA2 208913 at fs.png

PBB GE GGA2 208915 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 16: 23.46 – 23.52 Mb Chr 7: 121.99 – 122.02 Mb
PubMed search [1] [2]
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ADP-ribosylation factor-binding protein GGA2 is a protein that in humans is encoded by the GGA2 gene.[3][4][5]


This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.[5]


GGA2 has been shown to interact with RABEP1,[6] Sortilin 1,[7][8] BACE2[9] and CLINT1.[10][11]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (Apr 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". The Journal of Cell Biology. 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC 2175106Freely accessible. PMID 10747088. 
  4. ^ Boman AL, Zhang CJ, Zhu X, Kahn RA (Apr 2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Molecular Biology of the Cell. 11 (4): 1241–55. doi:10.1091/mbc.11.4.1241. PMC 14844Freely accessible. PMID 10749927. 
  5. ^ a b "Entrez Gene: GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2". 
  6. ^ Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (Jan 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". The EMBO Journal. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC 140067Freely accessible. PMID 12505986. 
  7. ^ Nielsen MS, Madsen P, Christensen EI, Nykjaer A, Gliemann J, Kasper D, Pohlmann R, Petersen CM (May 2001). "The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein". The EMBO Journal. 20 (9): 2180–90. doi:10.1093/emboj/20.9.2180. PMC 125444Freely accessible. PMID 11331584. 
  8. ^ Jacobsen L, Madsen P, Nielsen MS, Geraerts WP, Gliemann J, Smit AB, Petersen CM (Jan 2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Letters. 511 (1-3): 155–8. doi:10.1016/S0014-5793(01)03299-9. PMID 11821067. 
  9. ^ He X, Chang WP, Koelsch G, Tang J (Jul 2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2". FEBS Letters. 524 (1-3): 183–7. doi:10.1016/S0014-5793(02)03052-1. PMID 12135764. 
  10. ^ Wasiak S, Legendre-Guillemin V, Puertollano R, Blondeau F, Girard M, de Heuvel E, Boismenu D, Bell AW, Bonifacino JS, McPherson PS (Sep 2002). "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics". The Journal of Cell Biology. 158 (5): 855–62. doi:10.1083/jcb.200205078. PMC 2173151Freely accessible. PMID 12213833. 
  11. ^ Kalthoff C, Groos S, Kohl R, Mahrhold S, Ungewickell EJ (Nov 2002). "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi". Molecular Biology of the Cell. 13 (11): 4060–73. doi:10.1091/mbc.E02-03-0171. PMC 133614Freely accessible. PMID 12429846. 

Further reading[edit]