GGT1

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GGT1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GGT1, CD224, D22S672, D22S732, GGT, GGT 1, GTG, gamma-glutamyltransferase 1
External IDs MGI: 95706 HomoloGene: 68450 GeneCards: 2678
EC number 3.4.19.13
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_008116
NM_001305992

RefSeq (protein)

NP_001275762.1
NP_038265.2
NP_038347.2

NP_001292921.1
NP_032142.1

Location (UCSC) Chr 22: 24.58 – 24.63 Mb Chr 10: 75.56 – 75.59 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Gamma-glutamyltransferase 1, (GGT1) also known as CD224 (Cluster of Differentiation 224 ), is a human gene.[1]

Human gamma-glutamyltransferase catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. This heteroduplex enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma-glutamyltransferase protein family, of which many members have not yet been fully characterized. This gene encodes several transcript variants; studies suggest that many transcripts of this gene family may be non-functional or represent pseudogenes. The functional transcripts which have been fully characterized have been grouped and classified as type I gamma-glutamyltransferase. Complex splicing events may take place in a tissue-specific manner, resulting in marked dissimilarity in the 5' UTRs. Several 5' UTR transcript variants of the type I gene have been identified in different tissues and cancer cells.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.