Gamma-glutamyltransferase 1, (GGT1) also known as CD224 (Cluster of Differentiation 224 ), is a human gene.
Human gamma-glutamyltransferase catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. This heteroduplex enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma-glutamyltransferase protein family, of which many members have not yet been fully characterized. This gene encodes several transcript variants; studies suggest that many transcripts of this gene family may be non-functional or represent pseudogenes. The functional transcripts which have been fully characterized have been grouped and classified as type I gamma-glutamyltransferase. Complex splicing events may take place in a tissue-specific manner, resulting in marked dissimilarity in the 5' UTRs. Several 5' UTR transcript variants of the type I gene have been identified in different tissues and cancer cells.
Chikhi N, Holic N, Guellaen G, Laperche Y (1999). "Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species". Comp. Biochem. Physiol. B, Biochem. Mol. Biol.122 (4): 367–80. doi:10.1016/S0305-0491(99)00013-9. PMID10392451.
Indirani N, Hill PG (1977). "Partial purification and some properties of gamma-glutamyl transpeptidase from human bile". Biochim. Biophys. Acta483 (1): 57–62. doi:10.1016/0005-2744(77)90007-9. PMID18198.
Tate SS, Ross ME (1977). "Human kidney gamma-glutamyl transpeptidase. Catalytic properties, subunit structure, and localization of the gamma-glutamyl binding site on the light subunit". J. Biol. Chem.252 (17): 6042–5. PMID19463.
Welbourne TC (1978). "Cytoplasmic gamma-glutamyltransferase: isolation, product formation and physiological role". Current problems in clinical biochemistry8: 201–15. PMID28899.
Courtay C, Oster T, Michelet F, et al. (1992). "Gamma-glutamyltransferase: nucleotide sequence of the human pancreatic cDNA. Evidence for a ubiquitous gamma-glutamyltransferase polypeptide in human tissues". Biochem. Pharmacol.43 (12): 2527–33. doi:10.1016/0006-2952(92)90140-E. PMID1378736.
Pawlak A, Cohen EH, Octave JN, et al. (1990). "An alternatively processed mRNA specific for gamma-glutamyl transpeptidase in human tissues". J. Biol. Chem.265 (6): 3256–62. PMID1968061.
Pitot HC, Goodspeed D, Dunn T, et al. (1989). "Regulation of the expression of some genes for enzymes of glutathione metabolism in hepatotoxicity and hepatocarcinogenesis". Toxicol. Appl. Pharmacol.97 (1): 23–34. doi:10.1016/0041-008X(89)90052-5. PMID2563599.
Goodspeed DC, Dunn TJ, Miller CD, Pitot HC (1989). "Human gamma-glutamyl transpeptidase cDNA: comparison of hepatoma and kidney mRNA in the human and rat". Gene76 (1): 1–9. doi:10.1016/0378-1119(89)90002-4. PMID2568315.
Pawlak A, Wu SJ, Bulle F, et al. (1989). "Different gamma-glutamyl transpeptidase mRNAs are expressed in human liver and kidney". Biochem. Biophys. Res. Commun.164 (2): 912–8. doi:10.1016/0006-291X(89)91545-3. PMID2573352.
Bulle F, Mattei MG, Siegrist S, et al. (1987). "Assignment of the human gamma-glutamyl transferase gene to the long arm of chromosome 22". Hum. Genet.76 (3): 283–6. doi:10.1007/BF00283624. PMID2885259.replacement character in |last8= at position 7 (help)
Ikeda Y, Fujii J, Anderson ME, et al. (1995). "Involvement of Ser-451 and Ser-452 in the catalysis of human gamma-glutamyl transpeptidase". J. Biol. Chem.270 (38): 22223–8. doi:10.1074/jbc.270.38.22223. PMID7673200.
Ikeda Y, Fujii J, Taniguchi N, Meister A (1995). "Human gamma-glutamyl transpeptidase mutants involving conserved aspartate residues and the unique cysteine residue of the light subunit". J. Biol. Chem.270 (21): 12471–5. doi:10.1074/jbc.270.21.12471. PMID7759490.
Ikeda Y, Fujii J, Taniguchi N (1993). "Significance of Arg-107 and Glu-108 in the catalytic mechanism of human gamma-glutamyl transpeptidase. Identification by site-directed mutagenesis". J. Biol. Chem.268 (6): 3980–5. PMID8095045.