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Gamma-glutamyltransferase 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GGT1 ; CD224; D22S672; D22S732; GGT; GGT 1; GTG
External IDs OMIM612346 MGI95706 HomoloGene68450 ChEMBL: 5696 GeneCards: GGT1 Gene
EC number,,
Species Human Mouse
Entrez 2678 14598
Ensembl ENSG00000100031 ENSMUSG00000006345
UniProt P19440 Q60928
RefSeq (mRNA) NM_001032364 NM_001305992
RefSeq (protein) NP_001275762 NP_001292921
Location (UCSC) Chr 22:
24.58 – 24.63 Mb
Chr 10:
75.56 – 75.59 Mb
PubMed search [1] [2]

Gamma-glutamyltransferase 1, (GGT1) also known as CD224 (Cluster of Differentiation 224 ), is a human gene.[1]

Human gamma-glutamyltransferase catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. This heteroduplex enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma-glutamyltransferase protein family, of which many members have not yet been fully characterized. This gene encodes several transcript variants; studies suggest that many transcripts of this gene family may be non-functional or represent pseudogenes. The functional transcripts which have been fully characterized have been grouped and classified as type I gamma-glutamyltransferase. Complex splicing events may take place in a tissue-specific manner, resulting in marked dissimilarity in the 5' UTRs. Several 5' UTR transcript variants of the type I gene have been identified in different tissues and cancer cells.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.