Gamma-glutamyltransferase 5

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GGT5
Identifiers
AliasesGGT5, GGT-REL, GGTLA1, GGL, GGT 5, gamma-glutamyltransferase 5
External IDsOMIM: 137168 MGI: 1346063 HomoloGene: 55802 GeneCards: GGT5
EC number3.4.19.14
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for GGT5
Genomic location for GGT5
Band22q11.23Start24,219,654 bp[1]
End24,245,142 bp[1]
RNA expression pattern
PBB GE GGTLA1 205582 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001099781
NM_001099782
NM_001302464
NM_001302465
NM_004121

NM_011820
NM_001359425

RefSeq (protein)

NP_001093251
NP_001093252
NP_001289393
NP_001289394
NP_004112

NP_035950
NP_001346354

Location (UCSC)Chr 22: 24.22 – 24.25 MbChr 10: 75.59 – 75.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gamma-glutamyltransferase 5 is an enzyme that in humans is encoded by the GGT5 gene.[5][6][7][8]

Gamma-glutamyltransferase-like activity 1 (GGTLA1) is a member of a gene family with at least 4 members (GGTLA1, GGTLA2, GGTLA3 and GGTLA4). The enzyme encoded by GGTLA1 is related to, but distinct from, gamma-glutamyl transpeptidase (GGT). The GGTLA1 enzyme consists of a heavy and a light chain and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn't convert synthetic substrates that are commonly used to assay GGT. Its amino acid sequence shows an overall similarity of 39.5% with human GGT.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099998 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006344 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Heisterkamp N, Rajpert-De Meyts E, Uribe L, Forman HJ, Groffen J (Aug 1991). "Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase". Proc Natl Acad Sci U S A. 88 (14): 6303–7. doi:10.1073/pnas.88.14.6303. PMC 52071. PMID 1676842.
  6. ^ Morris C, Courtay C, Geurts van Kessel A, ten Hoeve J, Heisterkamp N, Groffen J (Apr 1993). "Localization of a gamma-glutamyl-transferase-related gene family on chromosome 22". Hum Genet. 91 (1): 31–6. doi:10.1007/bf00230218. PMID 8095916.
  7. ^ Heisterkamp N, Groffen J, Warburton D, Sneddon TP (Apr 2008). "The human gamma-glutamyltransferase gene family". Hum Genet. 123 (4): 321–32. doi:10.1007/s00439-008-0487-7. PMID 18357469.
  8. ^ a b "Entrez Gene: GGTLA1 gamma-glutamyltransferase-like activity 1".

Further reading[edit]