Growth-hormone-releasing hormone receptor

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Growth hormone releasing hormone receptor
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM139191 MGI95710 HomoloGene640 IUPHAR: 247 ChEMBL: 2032 GeneCards: GHRHR Gene
RNA expression pattern
PBB GE GHRHR 207825 s at tn.png
PBB GE GHRHR 211544 s at tn.png
PBB GE GHRHR 211545 at tn.png
More reference expression data
Species Human Mouse
Entrez 2692 14602
Ensembl ENSG00000106128 ENSMUSG00000004654
UniProt Q02643 P32082
RefSeq (mRNA) NM_000823 NM_001003685
RefSeq (protein) NP_000814 NP_001003685
Location (UCSC) Chr 7:
30.94 – 30.99 Mb
Chr 6:
55.38 – 55.39 Mb
PubMed search [1] [2]

The growth-hormone-releasing hormone receptor (GHRHR) is a G-protein-coupled receptor that binds growth hormone-releasing hormone. The GHRHR activates a Gs protein that causes a cascade of cAMP via Adenylate cyclase.[1]

This gene, expressed in the pituitary, encodes a receptor for growth-hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth-hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.[2]





  1. ^ Gaylinn BD (2002). "Growth hormone releasing hormone receptor". Recept. Channels 8 (3–4): 155–62. doi:10.1080/10606820213679. PMID 12529933. 
  2. ^ "Entrez Gene: GHRHR growth hormone releasing hormone receptor". 
  3. ^ Kovács M, Schally AV, Zarándi M, Groot K (1997). "Inhibition of GH release of rats by new potent antagonists of growth hormone-releasing hormone (GH-RH)". Peptides 18 (3): 431–8. doi:10.1016/S0196-9781(96)00334-8. PMID 9145432. 
  4. ^ Banks WA, Morley JE, Farr SA, Price TO, Ercal N, Vidaurre I, Schally AV (December 2010). "Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice". Proceedings of the National Academy of Sciences of the United States of America 107 (51): 22272–7. doi:10.1073/pnas.1016369107. PMC 3009756. PMID 21135231. 

Further reading[edit]

  • Gaylinn BD (1999). "Molecular and cell biology of the growth hormone-releasing hormone receptor.". Growth Horm. IGF Res. 9 Suppl A: 37–44. doi:10.1016/S1096-6374(99)80008-2. PMID 10429879. 
  • Lin-Su K, Wajnrajch MP (2003). "Growth Hormone Releasing Hormone (GHRH) and the GHRH Receptor.". Reviews in endocrine & metabolic disorders 3 (4): 313–23. doi:10.1023/A:1020949507265. PMID 12424433. 
  • Mayo KE (1992). "Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.". Mol. Endocrinol. 6 (10): 1734–44. doi:10.1210/me.6.10.1734. PMID 1333056. 
  • Squire J, Zhou A, Hassel BA et al. (1994). "Localization of the interferon-induced, 2-5A-dependent RNase gene (RNS4) to human chromosome 1q25.". Genomics 19 (1): 174–5. doi:10.1006/geno.1994.1033. PMID 7514564. 
  • Hashimoto K, Koga M, Motomura T et al. (1995). "Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas.". J. Clin. Endocrinol. Metab. 80 (10): 2933–9. doi:10.1210/jc.80.10.2933. PMID 7559877. 
  • Tang J, Lagacé G, Castagné J, Collu R (1995). "Identification of human growth hormone-releasing hormone receptor splicing variants.". J. Clin. Endocrinol. Metab. 80 (8): 2381–7. doi:10.1210/jc.80.8.2381. PMID 7629234. 
  • Gaylinn BD, Harrison JK, Zysk JR et al. (1993). "Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone.". Mol. Endocrinol. 7 (1): 77–84. doi:10.1210/me.7.1.77. PMID 7680413. 
  • Gaylinn BD, von Kap-Herr C, Golden WL, Thorner MO (1994). "Assignment of the human growth hormone-releasing hormone receptor gene (GHRHR) to 7p14 by in situ hybridization.". Genomics 19 (1): 193–5. doi:10.1006/geno.1994.1045. PMID 8188233. 
  • Wajnrajch MP, Gertner JM, Harbison MD et al. (1996). "Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse.". Nat. Genet. 12 (1): 88–90. doi:10.1038/ng0196-88. PMID 8528260. 
  • Netchine I, Talon P, Dastot F et al. (1998). "Extensive phenotypic analysis of a family with growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene.". J. Clin. Endocrinol. Metab. 83 (2): 432–6. doi:10.1210/jc.83.2.432. PMID 9467553. 
  • Petersenn S, Rasch AC, Heyens M, Schulte HM (1998). "Structure and regulation of the human growth hormone-releasing hormone receptor gene.". Mol. Endocrinol. 12 (2): 233–47. doi:10.1210/me.12.2.233. PMID 9482665. 
  • Maheshwari HG, Silverman BL, Dupuis J, Baumann G (1998). "Phenotype and genetic analysis of a syndrome caused by an inactivating mutation in the growth hormone-releasing hormone receptor: Dwarfism of Sindh.". J. Clin. Endocrinol. Metab. 83 (11): 4065–74. doi:10.1210/jc.83.11.4065. PMID 9814493. 
  • Salvatori R, Hayashida CY, Aguiar-Oliveira MH et al. (1999). "Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene.". J. Clin. Endocrinol. Metab. 84 (3): 917–23. doi:10.1210/jc.84.3.917. PMID 10084571. 
  • Morel G, Gallego R, Boulanger L et al. (2000). "Restricted presence of the growth hormone-releasing hormone receptor to somatotropes in rat and human pituitaries.". Neuroendocrinology 70 (2): 128–36. doi:10.1159/000054467. PMID 10461027. 
  • Rekasi Z, Czompoly T, Schally AV, Halmos G (2000). "Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers.". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10561–6. doi:10.1073/pnas.180313297. PMC 27064. PMID 10962031. 
  • Salvatori R, Fan X, Phillips JA et al. (2001). "Three new mutations in the gene for the growth hormone (gh)-releasing hormone receptor in familial isolated gh deficiency type ib.". J. Clin. Endocrinol. Metab. 86 (1): 273–9. doi:10.1210/jc.86.1.273. PMID 11232012. 
  • Kiaris H, Schally AV, Busto R et al. (2002). "Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs.". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 196–200. doi:10.1073/pnas.012590999. PMC 117538. PMID 11773624. 
  • Salvatori R, Fan X, Mullis PE et al. (2002). "Decreased expression of the GHRH receptor gene due to a mutation in a Pit-1 binding site.". Mol. Endocrinol. 16 (3): 450–8. doi:10.1210/me.16.3.450. PMID 11875102. 
  • Plonowski A, Schally AV, Busto R et al. (2003). "Expression of growth hormone-releasing hormone (GHRH) and splice variants of GHRH receptors in human experimental prostate cancers.". Peptides 23 (6): 1127–33. doi:10.1016/S0196-9781(02)00043-8. PMID 12126741. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.