Growth-hormone-releasing hormone receptor

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Growth hormone releasing hormone receptor
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GHRHR ; GHRFR; GRFR; IGHD1B
External IDs OMIM139191 MGI95710 HomoloGene640 IUPHAR: GHRH receptor ChEMBL: 2032 GeneCards: GHRHR Gene
RNA expression pattern
PBB GE GHRHR 207825 s at tn.png
PBB GE GHRHR 211544 s at tn.png
PBB GE GHRHR 211545 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2692 14602
Ensembl ENSG00000106128 ENSMUSG00000004654
UniProt Q02643 P32082
RefSeq (mRNA) NM_000823 NM_001003685
RefSeq (protein) NP_000814 NP_001003685
Location (UCSC) Chr 7:
30.98 – 31.03 Mb
Chr 6:
55.38 – 55.39 Mb
PubMed search [1] [2]

The growth-hormone-releasing hormone receptor (GHRHR) is a G-protein-coupled receptor that binds growth hormone-releasing hormone. The GHRHR activates a Gs protein that causes a cascade of cAMP via Adenylate cyclase.[1]

This gene, expressed in the pituitary, encodes a receptor for growth-hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth-hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.[2]

Ligands[edit]

Antagonists[edit]

References[edit]

  1. ^ Gaylinn BD (2002). "Growth hormone releasing hormone receptor". Recept. Channels 8 (3–4): 155–62. doi:10.1080/10606820213679. PMID 12529933. 
  2. ^ "Entrez Gene: GHRHR growth hormone releasing hormone receptor". 
  3. ^ Kovács M, Schally AV, Zarándi M, Groot K (1997). "Inhibition of GH release of rats by new potent antagonists of growth hormone-releasing hormone (GH-RH)". Peptides 18 (3): 431–8. doi:10.1016/S0196-9781(96)00334-8. PMID 9145432. 
  4. ^ Banks WA, Morley JE, Farr SA, Price TO, Ercal N, Vidaurre I, Schally AV (December 2010). "Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice". Proceedings of the National Academy of Sciences of the United States of America 107 (51): 22272–7. doi:10.1073/pnas.1016369107. PMID 21135231. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.