GJB5

From Wikipedia, the free encyclopedia
Jump to: navigation, search
GJB5
Identifiers
Aliases GJB5, CX31.1, gap junction protein beta 5
External IDs MGI: 95723 HomoloGene: 3858 GeneCards: 2709
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005268

NM_010291

RefSeq (protein)

NP_005259.1

NP_034421.1

Location (UCSC) Chr 1: 34.76 – 34.76 Mb Chr 4: 127.35 – 127.36 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Gap junction beta-5 protein (GJB5), also known as connexin-31.1 (Cx31.1), is a protein that in humans is encoded by the GJB5 gene.[1]

Function[edit]

Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family.[1]

References[edit]

Further reading[edit]

  • Canova C, Hashibe M, Simonato L, et al. (2009). "Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.". Cancer Res. 69 (7): 2956–65. doi:10.1158/0008-5472.CAN-08-2604. PMID 19339270. 
  • Richard G, Smith LE, Bailey RA, et al. (1998). "Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis.". Nat. Genet. 20 (4): 366–9. doi:10.1038/3840. PMID 9843209. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.