GLYCAM1

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glycosylation dependent cell adhesion molecule-1
Identifiers
Symbol GLYCAM1
Entrez 644076
HUGO 18023
RefSeq XM_927461
UniProt Q8IVK1
Other data
Locus Chr. 12 q13.2

Glycosylation-dependent cell adhesion molecule-1 (GLYCAM1) is a proteoglycan ligand expressed on cells of the high endothelial venules in lymph nodes. It is able to bind to the receptor L-selectin during inflammation, acting as a homing beacon for leukocytes expressing the receptor to enter the site of inflammation.[1] GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin.[citation needed] Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex.[2]

External links[edit]

References[edit]

  1. ^ Cotran, Ramzi S.; Kumar, Vinay; Collins, Tucker. Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. ISBN 0-7216-7335-X. [page needed]
  2. ^ Dowbenko, D; Kikuta, A; Fennie, C; Gillett, N; Lasky, L A (1993). "Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk". Journal of Clinical Investigation. 92 (2): 952–60. doi:10.1172/JCI116671. PMC 294935Freely accessible. PMID 8349827.