GME may refer to:
- GameStop, an American retailer
- Gelatine Manufacturers of Europe
- General Microelectronics, a defunct American semiconductor manufacturer
- General Motors Egypt
- General Motors Europe
- Green Mountain Energy, American company
- Grieg Music Education, Norwegian company
- Guardian Media Entertainment
- East Germanic languages
- GME of Deutscher Wetterdienst, weather prediction model of the German Weather Service
- Generic Modeling Environment
- Granulomatous meningoencephalitis, disease of the central nervous system of dogs and, rarely, cats
disambiguation page lists articles associated with the title GME.
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