GMP reductase

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guanosine monophosphate reductase
Symbol GMPR
Entrez 2766
HUGO 4376
OMIM 139265
RefSeq NM_006877
UniProt P36959
Other data
EC number
Locus Chr. 6 p23
guanosine monophosphate reductase 2
Symbol GMPR2
Entrez 51292
HUGO 4377
OMIM 610781
RefSeq NM_016576
UniProt Q9P2T1
Other data
Locus Chr. 14 q11.2

GMP reductase EC (Guanosine 5'-monophosphate oxidoreductase ) is an enzyme that catalyses the irreversible and NADPH-dependent reductive deamination of GMP into IMP.[1]

NADPH + guanosine 5-phosphate = NADP+ + inosine 5-phosphate + NH3

It converts nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and maintains intracellular balance of A and G nucleotides.

In melanocytic cells, GMP reductase gene expression may be regulated by MITF.[2]

See also[edit]


  1. ^ Andrews SC, Guest JR (Oct 1988). "Nucleotide sequence of the gene encoding the GMP reductase of Escherichia coli K12". The Biochemical Journal. 255 (1): 35–43. doi:10.1042/bj2550035. PMC 1135187Freely accessible. PMID 2904262. 
  2. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

External links[edit]

This article incorporates text from the public domain Pfam and InterPro IPR001093