From Wikipedia, the free encyclopedia
Jump to: navigation, search
Guanine nucleotide binding protein (G protein) alpha 12
Protein GNA12 PDB 1zca.png
PDB rendering based on 1zca.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GNA12 ; NNX3; RMP; gep
External IDs OMIM604394 MGI95767 HomoloGene22398 GeneCards: GNA12 Gene
RNA expression pattern
PBB GE GNA12 221737 at tn.png
More reference expression data
Species Human Mouse
Entrez 2768 14673
Ensembl ENSG00000146535 ENSMUSG00000000149
UniProt Q03113 P27600
RefSeq (mRNA) NM_001282440 NM_010302
RefSeq (protein) NP_001269369 NP_034432
Location (UCSC) Chr 7:
2.73 – 2.84 Mb
Chr 5:
140.76 – 140.83 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein subunit alpha-12 is a protein that in humans is encoded by the GNA12 gene.[1][2][3]


GNA12 has been shown to interact with ARHGEF1,[4] PPP5C,[5] ARHGEF12,[6][7] Heat shock protein 90kDa alpha (cytosolic), member A1[8] and TEC.[7]

See also[edit]


  1. ^ Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA (February 1993). "Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product". Mol Cell Biol 13 (2): 762–8. PMC 358958. PMID 8423800. 
  2. ^ Kumar RN, Shore SK, Dhanasekaran N (February 2006). "Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3". Oncogene 25 (6): 899–906. doi:10.1038/sj.onc.1209132. PMID 16247467. 
  3. ^ "Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12". 
  4. ^ Johnson EN, Seasholtz TM, Waheed AA et al. (December 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nat. Cell Biol. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662. 
  5. ^ Yamaguchi, Yoshiaki; Katoh Hironori; Mori Kazutoshi; Negishi Manabu (August 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Curr. Biol. (England) 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. ISSN 0960-9822. PMID 12176367. 
  6. ^ Fukuhara, S; Chikumi H; Gutkind J S (November 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Lett. (NETHERLANDS) 485 (2–3): 183–8. doi:10.1016/S0014-5793(00)02224-9. ISSN 0014-5793. PMID 11094164. 
  7. ^ a b Suzuki, Nobuchika; Nakamura Susumu; Mano Hiroyuki; Kozasa Tohru (January 2003). "Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (2): 733–8. doi:10.1073/pnas.0234057100. ISSN 0027-8424. PMC 141065. PMID 12515866. 
  8. ^ Vaiskunaite, R; Kozasa T; Voyno-Yasenetskaya T A (December 2001). "Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling". J. Biol. Chem. (United States) 276 (49): 46088–93. doi:10.1074/jbc.M108711200. ISSN 0021-9258. PMID 11598136. 

External links[edit]