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Protein GNA12 PDB 1zca.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases GNA12, NNX3, RMP, gep, G protein subunit alpha 12
External IDs MGI: 95767 HomoloGene: 22398 GeneCards: 2768
Genetically Related Diseases
Disease Name References
ulcerative colitis
RNA expression pattern
PBB GE GNA12 221737 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 7: 2.73 – 2.84 Mb Chr 5: 140.76 – 140.83 Mb
PubMed search [2] [3]
View/Edit Human View/Edit Mouse

Guanine nucleotide-binding protein subunit alpha-12 is a protein that in humans is encoded by the GNA12 gene.[4][5][6]


GNA12 has been shown to interact with ARHGEF1,[7] PPP5C,[8] ARHGEF12,[9][10] Heat shock protein 90kDa alpha (cytosolic), member A1[11] and TEC.[10]

See also[edit]


  1. ^ "". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA (February 1993). "Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product". Molecular and Cellular Biology. 13 (2): 762–8. PMC 358958free to read. PMID 8423800. 
  5. ^ Kumar RN, Shore SK, Dhanasekaran N (February 2006). "Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3". Oncogene. 25 (6): 899–906. doi:10.1038/sj.onc.1209132. PMID 16247467. 
  6. ^ "Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12". 
  7. ^ Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM (December 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nature Cell Biology. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662. 
  8. ^ Yamaguchi Y, Katoh H, Mori K, Negishi M (August 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Current Biology. 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. PMID 12176367. 
  9. ^ Fukuhara S, Chikumi H, Gutkind JS (November 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Letters. 485 (2-3): 183–8. doi:10.1016/S0014-5793(00)02224-9. PMID 11094164. 
  10. ^ a b Suzuki N, Nakamura S, Mano H, Kozasa T (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proceedings of the National Academy of Sciences of the United States of America. 100 (2): 733–8. doi:10.1073/pnas.0234057100. PMC 141065free to read. PMID 12515866. 
  11. ^ Vaiskunaite R, Kozasa T, Voyno-Yasenetskaya TA (December 2001). "Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling". The Journal of Biological Chemistry. 276 (49): 46088–93. doi:10.1074/jbc.M108711200. PMID 11598136. 

External links[edit]