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Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Symbols GNAI2 ; GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1
External IDs OMIM139360 MGI95772 HomoloGene55539 GeneCards: GNAI2 Gene
RNA expression pattern
PBB GE GNAI2 201040 at tn.png
More reference expression data
Species Human Mouse
Entrez 2771 14678
Ensembl ENSG00000114353 ENSMUSG00000032562
UniProt P04899 P08752
RefSeq (mRNA) NM_001166425 NM_008138
RefSeq (protein) NP_001159897 NP_032164
Location (UCSC) Chr 3:
50.23 – 50.26 Mb
Chr 9:
107.61 – 107.64 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein G(i), alpha-2 subunit is a protein that in humans is encoded by the GNAI2 gene.[1][2][3]


GNAI2 has been shown to interact with:


  1. ^ Didsbury JR, Ho YS, Snyderman R (Jan 1987). "Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA". FEBS Letters 211 (2): 160–4. doi:10.1016/0014-5793(87)81428-X. PMID 3100330. 
  2. ^ Magovcevic I, Ang SL, Seidman JG, Tolman CJ, Neer EJ, Morton CC (Jan 1992). "Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13". Genomics 12 (1): 125–9. doi:10.1016/0888-7543(92)90414-N. PMID 1733849. 
  3. ^ "Entrez Gene: GNAI2 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2". 
  4. ^ Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR (Oct 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". The Journal of Biological Chemistry 275 (41): 32129–34. doi:10.1074/jbc.M004577200. PMID 10906137. 
  5. ^ Marty C, Browning DD, Ye RD (Jun 2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Molecular and Cellular Biology 23 (11): 3847–58. doi:10.1128/mcb.23.11.3847-3858.2003. PMC 155206. PMID 12748287. 
  6. ^ Mochizuki N, Cho G, Wen B, Insel PA (Nov 1996). "Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2". Gene 181 (1-2): 39–43. doi:10.1016/s0378-1119(96)00456-8. PMID 8973305. 
  7. ^ Damaj BB, McColl SR, Neote K, Songqing N, Ogborn KT, Hébert CA, Naccache PH (Oct 1996). "Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops". FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 10 (12): 1426–34. PMID 8903513. 
  8. ^ Damaj BB, McColl SR, Mahana W, Crouch MF, Naccache PH (May 1996). "Physical association of Gi2alpha with interleukin-8 receptors". The Journal of Biological Chemistry 271 (22): 12783–9. PMID 8662698. 
  9. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  10. ^ Chen C, Zheng B, Han J, Lin SC (Mar 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". The Journal of Biological Chemistry 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. PMID 9079700. 
  11. ^ Zhou J, Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S (Feb 2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sciences 68 (13): 1457–69. doi:10.1016/s0024-3205(01)00939-0. PMID 11253162. 
  12. ^ Tall GG, Krumins AM, Gilman AG (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". The Journal of Biological Chemistry 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430. 

Further reading[edit]