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Guanine nucleotide binding protein (G protein), beta polypeptide 4
Protein GNB4 PDB 1a0r.png
PDB rendering based on 1a0r.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GNB4 ; CMTD1F
External IDs OMIM610863 MGI104581 HomoloGene69140 GeneCards: GNB4 Gene
Species Human Mouse
Entrez 59345 14696
Ensembl ENSG00000114450 ENSMUSG00000027669
UniProt Q9HAV0 P29387
RefSeq (mRNA) NM_021629 NM_013531
RefSeq (protein) NP_067642 NP_038559
Location (UCSC) Chr 3:
179.4 – 179.45 Mb
Chr 3:
32.58 – 32.62 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein subunit beta-4 is a protein that in humans is encoded by the GNB4 gene.[1][2][3]

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.[3]


  1. ^ Downes GB, Gautam N (Mar 2000). "The G protein subunit gene families". Genomics 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID 10644457. 
  2. ^ Ruiz-Velasco V, Ikeda SR, Puhl HL (Feb 2002). "Cloning, tissue distribution, and functional expression of the human G protein beta 4-subunit". Physiol Genomics 8 (1): 41–50. doi:10.1152/physiolgenomics.00085.2001. PMID 11842130. 
  3. ^ a b "Entrez Gene: GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4". 

Further reading[edit]