GNB4

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GNB4
Protein GNB4 PDB 1a0r.png
Identifiers
AliasesGNB4, CMTD1F, G protein subunit beta 4
External IDsOMIM: 610863 MGI: 104581 HomoloGene: 69140 GeneCards: GNB4
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for GNB4
Genomic location for GNB4
Band3q26.33Start179,396,088 bp[1]
End179,451,476 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021629

NM_013531
NM_001348062
NM_001348104
NM_001348105

RefSeq (protein)

NP_067642

NP_038559
NP_001334991
NP_001335033
NP_001335034

Location (UCSC)Chr 3: 179.4 – 179.45 MbChr 3: 32.58 – 32.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide-binding protein subunit beta-4 is a protein that in humans is encoded by the GNB4 gene.[5][6][7]

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114450 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027669 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Downes GB, Gautam N (Mar 2000). "The G protein subunit gene families". Genomics. 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID 10644457.
  6. ^ Ruiz-Velasco V, Ikeda SR, Puhl HL (Feb 2002). "Cloning, tissue distribution, and functional expression of the human G protein beta 4-subunit". Physiol Genomics. 8 (1): 41–50. doi:10.1152/physiolgenomics.00085.2001. PMID 11842130.
  7. ^ a b "Entrez Gene: GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4".

Further reading[edit]