GOLGA5

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Golgin A5
Identifiers
Symbols GOLGA5 ; GOLIM5; RFG5; ret-II
External IDs OMIM606918 MGI1351475 HomoloGene38009 GeneCards: GOLGA5 Gene
RNA expression pattern
PBB GE GOLGA5 218241 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9950 27277
Ensembl ENSG00000066455 ENSMUSG00000021192
UniProt Q8TBA6 Q9QYE6
RefSeq (mRNA) NM_005113 NM_001199004
RefSeq (protein) NP_005104 NP_001185933
Location (UCSC) Chr 14:
92.79 – 92.84 Mb
Chr 12:
102.47 – 102.5 Mb
PubMed search [1] [2]

Golgin subfamily A member 5 is a protein that in humans is encoded by the GOLGA5 gene.[1][2][3][4]

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins, whose members localize to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5.[4]

Interactions[edit]

GOLGA5 has been shown to interact with RAB1A.[5][6]

References[edit]

  1. ^ Ishizaka Y, Ochiai M, Tahira T, Sugimura T, Nagao M (Jul 1989). "Activation of the ret-II oncogene without a sequence encoding a transmembrane domain and transforming activity of two ret-II oncogene products differing in carboxy-termini due to alternative splicing". Oncogene 4 (6): 789–94. PMID 2734021. 
  2. ^ Klugbauer S, Demidchik EP, Lengfelder E, Rabes HM (Feb 1998). "Detection of a novel type of RET rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved RET-fused gene RFG5". Cancer Res 58 (2): 198–203. PMID 9443391. 
  3. ^ Oka T, Ungar D, Hughson FM, Krieger M (Apr 2004). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins". Mol Biol Cell 15 (5): 2423–35. doi:10.1091/mbc.E03-09-0699. PMC 404034. PMID 15004235. 
  4. ^ a b "Entrez Gene: GOLGA5 golgi autoantigen, golgin subfamily a, 5". 
  5. ^ Satoh, Ayano; Wang Yanzhuang; Malsam Jörg; Beard Matthew B; Warren Graham (Mar 2003). "Golgin-84 is a rab1 binding partner involved in Golgi structure". Traffic (Denmark) 4 (3): 153–61. doi:10.1034/j.1600-0854.2003.00103.x. ISSN 1398-9219. PMID 12656988. 
  6. ^ Diao, Aipo; Rahman Dinah; Pappin Darryl J C; Lucocq John; Lowe Martin (Jan 2003). "The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation". J. Cell Biol. (United States) 160 (2): 201–12. doi:10.1083/jcb.200207045. ISSN 0021-9525. PMC 2172652. PMID 12538640. 

Further reading[edit]