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Aliases GPA33, A33, glycoprotein A33
External IDs MGI: 1891703 HomoloGene: 4245 GeneCards: GPA33
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for GPA33
Genomic location for GPA33
Band 1q24.1 Start 167,052,836 bp[1]
End 167,166,479 bp[1]
RNA expression pattern
PBB GE GPA33 205929 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 167.05 – 167.17 Mb Chr 1: 166.13 – 166.17 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Cell surface A33 antigen is a protein that in humans is encoded by the GPA33 gene.[5][6][7]

The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143167 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000544 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Heath JK, White SJ, Johnstone CN, Catimel B, Simpson RJ, Moritz RL, Tu GF, Ji H, Whitehead RH, Groenen LC, Scott AM, Ritter G, Cohen L, Welt S, Old LJ, Nice EC, Burgess AW (Mar 1997). "The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily". Proc Natl Acad Sci U S A. 94 (2): 469–74. doi:10.1073/pnas.94.2.469. PMC 19536Freely accessible. PMID 9012807. 
  6. ^ Ritter G, Cohen LS, Nice EC, Catimel B, Burgess AW, Moritz RL, Ji H, Heath JK, White SJ, Welt S, Old LJ, Simpson RJ (Sep 1997). "Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium". Biochem Biophys Res Commun. 236 (3): 682–6. doi:10.1006/bbrc.1997.6966. PMID 9245713. 
  7. ^ a b "Entrez Gene: GPA33 glycoprotein A33 (transmembrane)". 

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