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Aliases GPAA1, GAA1, hGAA1, glycosylphosphatidylinositol anchor attachment 1
External IDs MGI: 1202392 HomoloGene: 37852 GeneCards: GPAA1
RNA expression pattern
PBB GE GPAA1 211060 x at fs.png

PBB GE GPAA1 201618 x at fs.png

PBB GE GPAA1 215690 x at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 8: 144.08 – 144.09 Mb Chr 15: 76.33 – 76.33 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Glycosylphosphatidylinositol anchor attachment 1 protein is a protein that in humans is encoded by the GPAA1 gene.[3][4]

Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains.[4]


GPAA1 has been shown to interact with PIGT[5][6] and PIGK.[6][7]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hiroi Y, Komuro I, Matsushita I, Aburatani H, Hosoda T, Nakahori Y, Medof ME, Yazaki Y (January 1999). "Assignment of the human GPAA1 gene, which encodes a product required for the attachment of glycosylphosphatidylinositols to proteins, at 8q24". Genomics. 54 (2): 354–5. doi:10.1006/geno.1998.5490. PMID 9828142. 
  4. ^ a b "Entrez Gene: GPAA1 glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)". 
  5. ^ Ohishi, K; Inoue N; Kinoshita T (August 2001). "PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8". EMBO J. England. 20 (15): 4088–98. doi:10.1093/emboj/20.15.4088. ISSN 0261-4189. PMC 149153Freely accessible. PMID 11483512. 
  6. ^ a b Vainauskas, Saulius; Maeda Yusuke; Kurniawan Henry; Kinoshita Taroh; Menon Anant K (August 2002). "Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex". J. Biol. Chem. United States. 277 (34): 30535–42. doi:10.1074/jbc.M205402200. ISSN 0021-9258. PMID 12052837. 
  7. ^ Ohishi, K; Inoue N; Maeda Y; Takeda J; Riezman H; Kinoshita T (May 2000). "Gaa1p and Gpi8p Are Components of a Glycosylphosphatidylinositol (GPI) Transamidase That Mediates Attachment of GPI to Proteins". Mol. Biol. Cell. UNITED STATES. 11 (5): 1523–33. doi:10.1091/mbc.11.5.1523. ISSN 1059-1524. PMC 14864Freely accessible. PMID 10793132. 

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