GPLD1

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GPLD1
Identifiers
Aliases GPLD1, GPIPLD, GPIPLDM, PIGPLD, PIPLD, glycosylphosphatidylinositol specific phospholipase D1
External IDs MGI: 106604 HomoloGene: 1152 GeneCards: GPLD1
RNA expression pattern
PBB GE GPLD1 206265 s at fs.png

PBB GE GPLD1 206264 at fs.png

PBB GE GPLD1 217405 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001503
NM_177483

NM_008156

RefSeq (protein)

NP_001494

n/a

Location (UCSC) Chr 6: 24.42 – 24.5 Mb Chr 13: 24.94 – 24.99 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Phosphatidylinositol-glycan-specific phospholipase D is an enzyme that in humans is encoded by the GPLD1 gene.[3][4]

Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane.[4]

Interactions[edit]

GPLD1 has been shown to interact with Apolipoprotein A1[5] and APOA4.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Schofield JN, Rademacher TW (Dec 2000). "Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene". Biochim Biophys Acta. 1494 (1–2): 189–94. doi:10.1016/s0167-4781(00)00194-9. PMID 11072085. 
  4. ^ a b "Entrez Gene: GPLD1 glycosylphosphatidylinositol specific phospholipase D1". 
  5. ^ a b Deeg, M A; Bierman E L; Cheung M C (Mar 2001). "GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex". J. Lipid Res. United States. 42 (3): 442–51. ISSN 0022-2275. PMID 11254757. 

Further reading[edit]