GPR101

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GPR101
Identifiers
Aliases GPR101, GPCR6, PAGH2, G protein-coupled receptor 101
External IDs MGI: 2685211 HomoloGene: 14273 GeneCards: GPR101
RNA expression pattern
PBB GE GPR101 gnf1h01265 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_054021

NM_001033360

RefSeq (protein)

NP_473362

NP_001028532.1
NP_001028532

Location (UCSC) Chr X: 137.03 – 137.03 Mb Chr X: 57.5 – 57.5 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 101 is a protein that in humans is encoded by the GPR101 gene.[3][4]

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[4]

Clinical significance[edit]

A duplication event in GPR101 is implicated in cases of gigantism and acromegaly.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155. 
  4. ^ a b "Entrez Gene: GPR101 G protein-coupled receptor 101". 
  5. ^ Trivellin G, Daly AF, Faucz FR, Yuan B, Rostomyan L, Larco DO, Schernthaner-Reiter MH, Szarek E, Leal LF, Caberg JH, Castermans E, Villa C, Dimopoulos A, Chittiboina P, Xekouki P, Shah N, Metzger D, Lysy PA, Ferrante E, Strebkova N, Mazerkina N, Zatelli MC, Lodish M, Horvath A, de Alexandre RB, Manning AD, Levy I, Keil MF, Sierra MD, Palmeira L, Coppieters W, Georges M, Naves LA, Jamar M, Bours V, Wu TJ, Choong CS, Bertherat J, Chanson P, Kamenický P, Farrell WE, Barlier A, Quezado M, Bjelobaba I, Stojilkovic SS, Wess J, Costanzi S, Liu P, Lupski JR, Beckers A, Stratakis CA (2014). "Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation". N. Engl. J. Med. 371: 2363–74. doi:10.1056/NEJMoa1408028. PMID 25470569. 

Further reading[edit]

  • Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.