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Adhesion G protein-coupled receptor G5
Symbols ADGRG5 ; GPR114; PGR27
External IDs MGI2685955 HomoloGene17828 IUPHAR: GeneCards: ADGRG5 Gene
Species Human Mouse
Entrez 221188 382045
Ensembl ENSG00000159618 ENSMUSG00000061577
UniProt Q8IZF4 Q3V3Z3
RefSeq (mRNA) NM_001304376 NM_001033468
RefSeq (protein) NP_001291305 NP_001028640
Location (UCSC) Chr 16:
57.54 – 57.59 Mb
Chr 8:
94.92 – 94.94 Mb
PubMed search [1] [2]

G protein-coupled receptor 114 is a protein encoded by the ADGRG5 gene.[1][2][3] GPR114 is a member of the adhesion GPCR family.[4][5] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[6]

GPR114 mRNA is specifically expressed in human eosinophils as well as in mouse lymphocytes, monocytes, macrophage, and dendritic cells.[7]


The cyclic adenosine monophosphate (cAMP) assay in overexpressing HEK293 cells has demonstrated coupling of GPR114 to Gαs protein.[8]


  1. ^ "Entrez Gene: GPR114 G protein-coupled receptor 114". 
  2. ^ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. 
  3. ^ Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.". Pharmacological reviews 67 (2): 338–67. doi:10.1124/pr.114.009647. PMID 25713288. 
  4. ^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  5. ^ Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage.". Science signaling 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. 
  6. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. 
  7. ^ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews 67 (2): 338–67. doi:10.1124/pr.114.009647. PMID 25713288. 
  8. ^ Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X (Apr 2012). "Signaling property study of adhesion G-protein-coupled receptors". FEBS Letters 586 (8): 1214–9. doi:10.1016/j.febslet.2012.03.014. PMID 22575658. 

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