GPR114

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Adhesion G protein-coupled receptor G5
Identifiers
Symbols ADGRG5 ; GPR114; PGR27
External IDs MGI2685955 HomoloGene17828 IUPHAR: GeneCards: ADGRG5 Gene
Orthologs
Species Human Mouse
Entrez 221188 382045
Ensembl ENSG00000159618 ENSMUSG00000061577
UniProt Q8IZF4 Q3V3Z3
RefSeq (mRNA) NM_001304376 NM_001033468
RefSeq (protein) NP_001291305 NP_001028640
Location (UCSC) Chr 16:
57.54 – 57.59 Mb
Chr 8:
94.92 – 94.94 Mb
PubMed search [1] [2]

G protein-coupled receptor 114 is a protein encoded by the ADGRG5 gene.[1][2][3] GPR114 is a member of the adhesion GPCR family.[4][5] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[6]

GPR114 mRNA is specifically expressed in human eosinophils as well as in mouse lymphocytes, monocytes, macrophage, and dendritic cells.[7]

Signaling[edit]

The cyclic adenosine monophosphate (cAMP) assay in overexpressing HEK293 cells has demonstrated coupling of GPR114 to Gαs protein.[8]

References[edit]

  1. ^ "Entrez Gene: GPR114 G protein-coupled receptor 114". 
  2. ^ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. 
  3. ^ Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.". Pharmacological reviews 67 (2): 338–67. PMID 25713288. 
  4. ^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  5. ^ Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage.". Science signaling 6 (276): re3. PMID 23695165. 
  6. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC et al. (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. 
  7. ^ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R et al. (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews 67 (2): 338–67. doi:10.1124/pr.114.009647. PMID 25713288. 
  8. ^ Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X (Apr 2012). "Signaling property study of adhesion G-protein-coupled receptors". FEBS Letters 586 (8): 1214–9. doi:10.1016/j.febslet.2012.03.014. PMID 22575658. 

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