GPR116

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ADGRF5
Identifiers
AliasesADGRF5, KPG_001, GPR116, adhesion G protein-coupled receptor F5
External IDsMGI: 2182928 HomoloGene: 9065 GeneCards: ADGRF5
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for ADGRF5
Genomic location for ADGRF5
Band6p12.3Start46,852,512 bp[1]
End46,954,943 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001098518
NM_015234

NM_001081178
NM_001357332

RefSeq (protein)

NP_001091988
NP_056049

NP_001074647
NP_001344261

Location (UCSC)Chr 6: 46.85 – 46.95 MbChr 17: 43.36 – 43.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 116 is a protein that in humans is encoded by the GPR116 gene.[5][6][7] GPR116 has now been shown to play an essential role in the regulation of lung surfactant homeostasis.[8][9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000069122 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056492 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Stacey, edited by S Yona, M Stacey (2010). Adhesion-GPCRs : structure to function. New York: Springer Science+Business Media. ISBN 978-1-4419-7912-4.
  6. ^ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584.
  7. ^ "Entrez Gene: GPR116 G protein-coupled receptor 116".
  8. ^ Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B (May 2013). "Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116". Cell Reports. 3 (5): 1457–64. doi:10.1016/j.celrep.2013.04.019. PMC 3695742. PMID 23684610.
  9. ^ Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S (2013). "Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D". PLOS ONE. 8 (7): e69451. doi:10.1371/journal.pone.0069451. PMC 3726689. PMID 23922714.

Further reading[edit]