Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.  
The gene product of GPR12 is an
orphan receptor, meaning that its endogenous ligand is currently unknown. Gene disruption of GPR12 in mice results in dyslipidemia and obesity.
Ligands [ edit ]
References [ edit ]
^ a b c
GRCh38: Ensembl release 89: ENSG00000132975 - Ensembl, May 2017
^ a b c
GRCm38: Ensembl release 89: ENSMUSG00000041468 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T (December 1993). "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system". FEBS Letters. 336 (2): 317–22. doi: . 10.1016/0014-5793(93)80828-I PMID 8262253. S2CID 31345248.
Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–9. doi: 10.1006/geno.1995.1154. PMID 8530049.
"Entrez Gene: GPR12 G protein-coupled receptor 12".
Bjursell M, Gerdin AK, Jönsson M, Surve VV, Svensson L, Huang XF, et al. (September 2006). "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice". Biochemical and Biophysical Research Communications. 348 (2): 359–66. doi: 10.1016/j.bbrc.2006.07.090. PMID 16887097.
Brown KJ, Laun AS, Song ZH (November 2017). "Cannabidiol, a novel inverse agonist for GPR12". Biochemical and Biophysical Research Communications. 493 (1): 451–454. doi: 10.1016/j.bbrc.2017.09.001. PMC . 5849771 PMID 28888984.
Further reading [ edit ]
Uhlenbrock K, Huber J, Ardati A, Busch AE, Kostenis E (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells". Cellular Physiology and Biochemistry. 13 (2): 75–84. doi: 10.1159/000070251. PMID 12649592. S2CID 45156405.