GPR12

From Wikipedia, the free encyclopedia
Jump to: navigation, search
GPR12
Identifiers
Aliases GPR12, GPCR12, GPCR21, PPP1R84, G protein-coupled receptor 12
External IDs MGI: 101909 HomoloGene: 3868 GeneCards: GPR12
RNA expression pattern
PBB GE GPR12 214558 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005288

NM_001010941
NM_008151

RefSeq (protein)

NP_005279

NP_001010941
NP_032177

Location (UCSC) Chr 13: 26.76 – 26.76 Mb Chr 5: 146.58 – 146.59 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.[3][4][5]

The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene disruption of GPR12 in mice results in dyslipidemia and obesity[6].


References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T (Jan 1994). "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system". FEBS Lett. 336 (2): 317–322. PMID 8262253. doi:10.1016/0014-5793(93)80828-I. 
  4. ^ Song ZH, Modi W, Bonner TI (Feb 1996). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–349. PMID 8530049. doi:10.1006/geno.1995.1154. 
  5. ^ "Entrez Gene: GPR12 G protein-coupled receptor 12". 
  6. ^ Bjursell, Mikael; Gerdin, Anna-Karin; Jönsson, Marie; Surve, Vikas V.; Svensson, Lennart; Huang, Xu-Feng; Törnell, Jan; Bohlooly-Y, Mohammad (2006-09-22). "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice". Biochemical and Biophysical Research Communications. 348 (2): 359–366. ISSN 0006-291X. PMID 16887097. doi:10.1016/j.bbrc.2006.07.090. 

Further reading[edit]