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Free fatty acid receptor 4
Symbols FFAR4 ; BMIQ10; GPR120; GPR129; GT01; O3FAR1; PGR4
External IDs OMIM609044 MGI2147577 HomoloGene18769 IUPHAR: 127 ChEMBL: 5339 GeneCards: FFAR4 Gene
Species Human Mouse
Entrez 338557 107221
Ensembl ENSG00000186188 ENSMUSG00000054200
UniProt Q5NUL3 Q7TMA4
RefSeq (mRNA) NM_001195755 NM_181748
RefSeq (protein) NP_001182684 NP_861413
Location (UCSC) Chr 10:
93.57 – 93.6 Mb
Chr 19:
38.1 – 38.11 Mb
PubMed search [1] [2]

G-protein coupled receptor 120 is a protein that in humans is encoded by the GPR120 gene.[1][2]

GPR120 is a member of the rhodopsin family of G protein-coupled receptors (GPRs).[1][2]

GPR120 has also been shown to mediate the anti-inflammatory and insulin-sensitizing effects of omega 3 fatty acids.[3] Lack of GPR120 is responsible for reduced fat metabolism, thereby leading to obesity.[4]

Additionally, GPR120 has been implicated to be involved in the ability to taste fats. [5] It is expressed in taste bud cells (specifically cell type II, which contain other G-protein coupled taste receptors), and its absence leads to reduced preference to two types of fatty acid (linoleic acid and oleic acid), as well as decreased neuronal response to oral fatty acids. [6]


  1. ^ a b Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Nov 2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Lett 554 (3): 381–8. doi:10.1016/S0014-5793(03)01196-7. PMID 14623098. 
  2. ^ a b "Entrez Gene: GPR120 G protein-coupled receptor 120". 
  3. ^ Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li P, Lu WJ, Watkins SM, Olefsky JM (2010). "GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects". Cell 142 (5): 687–698. doi:10.1016/j.cell.2010.07.041. PMC 2956412. PMID 20813258. 
  4. ^ Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L; et al. (2012). "Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human". Nature 483 (7389): 350–4. doi:10.1038/nature10798. PMID 22343897. 
  5. ^ PubMed
  6. ^ PubMed

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