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G protein-coupled receptor 123
Symbols GPR123 ; FLJ25875; FLJ37356
External IDs OMIM612302 MGI1277167 HomoloGene18582 IUPHAR: 197 GeneCards: GPR123 Gene
Species Human Mouse
Entrez 84435 52389
Ensembl ENSG00000197177 ENSMUSG00000025475
UniProt Q86SQ6 Q6PHM3
RefSeq (mRNA) NM_001083909 NM_177469
RefSeq (protein) NP_001077378 NP_803420
Location (UCSC) Chr 10:
134.88 – 134.95 Mb
Chr 7:
139.83 – 139.88 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 123 is a protein that in humans is encoded by the GPR123 gene.[1][2] It is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[3][4][5]


  1. ^ Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (Feb 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun 301 (3): 725–34. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841. 
  2. ^ "Entrez Gene: GPR123 G protein-coupled receptor 123". 
  3. ^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  4. ^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. 
  5. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. 

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