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Aliases GPR143, NYS6, OA1, G protein-coupled receptor 143
External IDs MGI: 107193 HomoloGene: 230 GeneCards: 4935
RNA expression pattern
PBB GE GPR143 206696 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr X: 9.73 – 9.79 Mb Chr X: 152.78 – 152.81 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse
Ocular albinism type 1 protein
Symbol Ocular_alb
Pfam PF02101
Pfam clan CL0192
InterPro IPR001414

G-protein coupled receptor 143 is a protein encoded by the GPR143 gene in humans.[3][4][5]

Ocular albinism type 1 protein is a conserved integral membrane protein with seven transmembrane domains. It is expressed in the eye and epidermal melanocytes.[5]

The GPR143 gene is regulated by the Microphthalmia-associated transcription factor.[6][7]

L-DOPA is an endogenous ligand for OA1.[8]


GPR143 has been shown to interact with GNAI1.[4]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Bassi MT, Schiaffino MV, Renieri A, De Nigris F, Galli L, Bruttini M, Gebbia M, Bergen AA, Lewis RA, Ballabio A (Sep 1995). "Cloning of the gene for ocular albinism type 1 from the distal short arm of the X chromosome". Nat Genet. 10 (1): 13–9. doi:10.1038/ng0595-13. PMID 7647783. 
  4. ^ a b Schiaffino MV, d'Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K, Puri C, Bassi MT, Colla C, De Luca M, Tacchetti C, Ballabio A (Sep 1999). "Ocular albinism: evidence for a defect in an intracellular signal transduction system". Nat Genet. 23 (1): 108–12. doi:10.1038/12715. PMID 10471510. 
  5. ^ a b "Entrez Gene: GPR143 G protein-coupled receptor 143". 
  6. ^ Vetrini F, Auricchio A, Du J, et al. (2004). "The microphthalmia transcription factor (Mitf) controls expression of the ocular albinism type 1 gene: link between melanin synthesis and melanosome biogenesis". Mol. Cell. Biol. 24 (15): 6550–9. doi:10.1128/MCB.24.15.6550-6559.2004. PMC 444869free to read. PMID 15254223. 
  7. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  8. ^ Lopez VM, Decatur CL, Stamer WD, Lynch RM, McKay BS (September 2008). Barsh GS, ed. "L-DOPA is an endogenous ligand for OA1". PLoS Biol. 6 (9): e236. doi:10.1371/journal.pbio.0060236. PMC 2553842free to read. PMID 18828673. 

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