GPR152

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G protein-coupled receptor 152
Identifiers
Symbols GPR152 ; PGR5
External IDs MGI2685519 HomoloGene35474 IUPHAR: 138 GeneCards: GPR152 Gene
RNA expression pattern
PBB GE GPR152 gnf1h05602 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 390212 269053
Ensembl ENSG00000175514 ENSMUSG00000044724
UniProt Q8TDT2 Q8BXS7
RefSeq (mRNA) NM_206997 NM_206973
RefSeq (protein) NP_996880 NP_996856
Location (UCSC) Chr 11:
67.45 – 67.45 Mb
Chr 19:
4.14 – 4.15 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 152 is a protein that in humans is encoded by the GPR152 gene.[1][2]


Model organisms[edit]

Model organisms have been used in the study of GPR152 function. A conditional knockout mouse line called Gpr152tm1b(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[3] Male and female animals underwent a standardized phenotypic screen[4] to determine the effects of deletion.[5][6][7][8] Additional screens performed: - In-depth immunological phenotyping[9]



References[edit]

  1. ^ Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proc Natl Acad Sci U S A 100 (8): 4903–8. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517. 
  2. ^ "Entrez Gene: GPR152 G protein-coupled receptor 152". 
  3. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  4. ^ a b "International Mouse Phenotyping Consortium". 
  5. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750. 
  6. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  7. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  8. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMID 23870131. 
  9. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading[edit]