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Aliases GPR158
External IDs MGI: 2441697 HomoloGene: 19381 GeneCards: 57512
RNA expression pattern
PBB GE GPR158 gnf1h10155 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 10: 25.18 – 25.6 Mb Chr 2: 21.37 – 21.83 Mb
PubMed search [1] [2]
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Probable G-protein coupled receptor 158 is a protein that in humans is encoded by the GPR158 gene.[1]

GPR158 is an orphan class C GPCR. It is highly expressed in the brain where it binds to RGS7, an inhibitor of Gi/o-coupled GPCR signaling, localizing it to the plasma membrane.[2]

GPR158 is also expressed at lower levels in other organs. It shows an unusual subcellular localization pattern, being found at both the plasma membrane and in the nucleus.[3]

GPR158 is an androgen-regulated gene that stimulates cell proliferation in prostate cancer cell lines. It is linked to neuroendocrine differentiation.[4]


  1. ^ "Entrez Gene: GPR158 G protein-coupled receptor 158". 
  2. ^ Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA (2012). "GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes". J. Cell Biol. 197 (6): 711–9. doi:10.1083/jcb.201202123. PMC 3373406. PMID 22689652. 
  3. ^ Patel N, Itakura T, Gonzalez JM, Schwartz SG, Fini ME (2013). "GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role". PLoS ONE 8 (2): e57843. doi:10.1371/journal.pone.0057843. PMC 3581496. PMID 23451275.  open access publication - free to read
  4. ^ Patel N, Itakura T, Jeong S, Liao CP, Roy-Burman P, Zandi E, Groshen S, Pinski J, Coetzee GA, Gross ME, Fini ME (2015). "Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression". PLoS ONE 10 (2): e0117758. doi:10.1371/journal.pone.0117758. PMC 4333349. PMID 25693195.  open access publication - free to read