GPR158

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GPR158
Identifiers
Aliases GPR158, G protein-coupled receptor 158
External IDs MGI: 2441697 HomoloGene: 19381 GeneCards: GPR158
Gene location (Human)
Chromosome 10 (human)
Chr. Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for GPR158
Genomic location for GPR158
Band 10p12.1 Start 25,175,062 bp[1]
End 25,602,226 bp[1]
RNA expression pattern
PBB GE GPR158 gnf1h10155 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020752

NM_001004761
NM_175706

RefSeq (protein)

NP_065803

NP_001004761

Location (UCSC) Chr 10: 25.18 – 25.6 Mb Chr 10: 21.37 – 21.83 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 158 is a protein that in humans is encoded by the GPR158 gene.[5]

GPR158 is an orphan class C GPCR. It is highly expressed in the brain where it binds to RGS7, an inhibitor of Gi/o-coupled GPCR signaling, localizing it to the plasma membrane.[6]

GPR158 is also expressed at lower levels in other organs. It shows an unusual subcellular localization pattern, being found at both the plasma membrane and in the nucleus.[7]

GPR158 is an androgen-regulated gene that stimulates cell proliferation in prostate cancer cell lines. It is linked to neuroendocrine differentiation.[8]

References[edit]