GPR177

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WLS
Identifiers
Aliases WLS, C1orf139, EVI, GPR177, MRP, mig-14, wntless Wnt ligand secretion mediator
External IDs MGI: 1915401 HomoloGene: 11779 GeneCards: WLS
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for WLS
Genomic location for WLS
Band 1p31.3 Start 68,098,473 bp[1]
End 68,233,120 bp[1]
RNA expression pattern
PBB GE GPR177 221958 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001002292
NM_001193334
NM_024911

NM_026582

RefSeq (protein)

NP_001002292
NP_001180263
NP_079187

NP_080858

Location (UCSC) Chr 1: 68.1 – 68.23 Mb Chr 1: 159.84 – 159.94 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

G protein-coupled receptor 177 (GPR177), commonly known as Wntless, is a human gene[5] that encodes a receptor for Wnt proteins in Wnt-secreting cells.[6]

Wntless was shown to be a cargo for the retromer complex.[6] It has been found essential for hair follicle induction.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116729 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028173 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: GPR177 G protein-coupled receptor 177". 
  6. ^ a b Eaton S (January 2008). "Retromer retrieves wntless". Developmental Cell. 14 (1): 4–6. PMID 18194646. doi:10.1016/j.devcel.2007.12.014. 
  7. ^ Fu J, Hsu W (April 2013). "Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis". The Journal of Investigative Dermatology. 133 (4): 890–8. PMID 23190887. doi:10.1038/jid.2012.407. 

Further reading[edit]

  • Bänziger C, Soldini D, Schütt C, Zipperlen P, Hausmann G, Basler K (May 2006). "Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells". Cell. 125 (3): 509–22. PMID 16678095. doi:10.1016/j.cell.2006.02.049. 
  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. PMID 16303743. doi:10.1093/dnares/12.2.117. 
  • Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. PMC 403697Freely accessible. PMID 12975309. doi:10.1101/gr.1293003. 
  • Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. PMID 12761501. doi:10.1038/sj.onc.1206406. 

See also[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.