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AliasesGPR3, ACCA, G protein-coupled receptor 3
External IDsOMIM: 600241 MGI: 101908 HomoloGene: 31303 GeneCards: GPR3
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for GPR3
Genomic location for GPR3
Band1p36.11Start27,392,622 bp[1]
End27,395,814 bp[1]
RNA expression pattern
PBB GE GPR3 214613 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 27.39 – 27.4 MbChr 4: 133.21 – 133.21 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene.[5][6] The protein encoded by this gene is a member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction.


GPR3 activates adenylate cyclase in the absence of ligand.[7] GPR3 is expressed in mammalian oocytes where it maintains meiotic arrest and is thought to be a communication link between oocytes and the surrounding somatic tissue.[8] It has been proposed that sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine (SPC) are GPR3 ligands,[9][10] however this result was not confirmed in a β-arrestin recruitment assay.[11]

Mice lacking GPR3 were found to develop late-onset obesity owing to decreased UCP-1 expression in brown adipose tissue and reduced thermogenic capacity.[12]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181773 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049649 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (Mar 1995). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics. 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID 7851889.
  6. ^ "Entrez Gene: GPR3 G protein-coupled receptor 3".
  7. ^ Eggerickx D, Denef JF, Labbe O, Hayashi Y, Refetoff S, Vassart G, Parmentier M, Libert F (August 1995). "Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase". Biochem. J. 309 (Pt 3): 837–43. doi:10.1042/bj3090837. PMC 1135708. PMID 7639700.
  8. ^ Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, Pendola FL, Knowles BB, Eppig JJ, Jaffe LA (December 2004). "The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes". Science. 306 (5703): 1947–50. Bibcode:2004Sci...306.1947M. doi:10.1126/science.1103974. PMID 15591206. S2CID 37342089.
  9. ^ Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cell. Signal. 14 (11): 941–53. doi:10.1016/S0898-6568(02)00041-4. PMID 12220620.
  10. ^ Hinckley M, Vaccari S, Horner K, Chen R, Conti M (November 2005). "The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes". Dev. Biol. 287 (2): 249–61. doi:10.1016/j.ydbio.2005.08.019. PMID 16229830.
  11. ^ Yin H, Chu A, Li W, Wang B, Shelton F, Otero F, Nguyen DG, Caldwell JS, Chen YA (May 2009). "Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay". J. Biol. Chem. 284 (18): 12328–38. doi:10.1074/jbc.M806516200. PMC 2673301. PMID 19286662.
  12. ^ Godlewski, Grzegorz; Jourdan, Tony; Szanda, Gergő; Tam, Joseph; Cinar, Resat; Harvey-White, Judith; Liu, Jie; Mukhopadhyay, Bani; Pacher, Pál; Ming Mo, Fong; Osei-Hyiaman, Douglas (2015-10-12). "Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue". Scientific Reports. 5: 14953. Bibcode:2015NatSR...514953G. doi:10.1038/srep14953. ISSN 2045-2322. PMC 4601089. PMID 26455425.

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