GPR3

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GPR3
Identifiers
Aliases GPR3, ACCA, G protein-coupled receptor 3
External IDs MGI: 101908 HomoloGene: 31303 GeneCards: GPR3
Targeted by Drug
sphingosine 1-phosphate[1]
RNA expression pattern
PBB GE GPR3 214613 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005281

NM_008154

RefSeq (protein)

NP_005272.1

NP_032180.1

Location (UCSC) Chr 1: 27.39 – 27.4 Mb Chr 4: 133.21 – 133.21 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene.[4][5] The protein encoded by this gene is a member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction.

Function[edit]

GPR3 activates adenylate cyclase in the absence of ligand.[6] GPR3 is expressed in mammalian oocytes where it maintains meiotic arrest and is thought to be a communication link between oocytes and the surrounding somatic tissue.[7] It has been proposed that sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine (SPC) are GPR3 ligands,[8][9] however this result was not confirmed in a β-arrestin recruitment assay.[10]

References[edit]

  1. ^ "Drugs that physically interact with G-protein coupled receptor 3 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (Mar 1995). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics. 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID 7851889. 
  5. ^ "Entrez Gene: GPR3 G protein-coupled receptor 3". 
  6. ^ Eggerickx D, Denef JF, Labbe O, Hayashi Y, Refetoff S, Vassart G, Parmentier M, Libert F (August 1995). "Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase". Biochem. J. 309 ( Pt 3) (Pt 3): 837–43. PMC 1135708Freely accessible. PMID 7639700. 
  7. ^ Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, Pendola FL, Knowles BB, Eppig JJ, Jaffe LA (December 2004). "The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes". Science. 306 (5703): 1947–50. doi:10.1126/science.1103974. PMID 15591206. 
  8. ^ Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cell. Signal. 14 (11): 941–53. doi:10.1016/S0898-6568(02)00041-4. PMID 12220620. 
  9. ^ Hinckley M, Vaccari S, Horner K, Chen R, Conti M (November 2005). "The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes". Dev. Biol. 287 (2): 249–61. doi:10.1016/j.ydbio.2005.08.019. PMID 16229830. 
  10. ^ Yin H, Chu A, Li W, Wang B, Shelton F, Otero F, Nguyen DG, Caldwell JS, Chen YA (May 2009). "Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay". J. Biol. Chem. 284 (18): 12328–38. doi:10.1074/jbc.M806516200. PMC 2673301Freely accessible. PMID 19286662. 

Further reading[edit]