GPR77

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C5AR2
Identifiers
AliasesC5AR2, C5L2, GPF77, GPR77, complement component 5a receptor 2
External IDsMGI: 2442013 HomoloGene: 49549 GeneCards: C5AR2
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for C5AR2
Genomic location for C5AR2
Band19q13.32Start47,332,147 bp[1]
End47,347,327 bp[1]
RNA expression pattern
PBB GE GPR77 221149 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001271749
NM_001271750
NM_018485

NM_001146005
NM_176912

RefSeq (protein)

NP_001258678
NP_001258679
NP_060955

NP_001139477
NP_795886

Location (UCSC)Chr 19: 47.33 – 47.35 MbChr 7: 16.23 – 16.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

C5a anaphylatoxin chemotactic receptor C5a2 also known as C5L2, G protein-coupled receptor 77, is a protein that in humans is encoded by the C5AR2 gene.[5][6]

Function[edit]

The anaphylatoxins C3a, C4a, and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5a2 is coexpressed with the C5a receptor, (C5a1, C5aR, C5R1, CD88), on polymorphonuclear neutrophils and may modulate C5a1 activity.[6][7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134830 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074361 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF (Feb 2001). "Identification of four novel human G protein-coupled receptors expressed in the brain". Brain Res Mol Brain Res. 86 (1–2): 13–22. doi:10.1016/S0169-328X(00)00242-4. PMID 11165367. 
  6. ^ a b "HUGO". 
  7. ^ Gerard NP, Lu B, Liu P, Craig S, Fujiwara Y, Okinaga S, Gerard C (December 2005). "An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2". J. Biol. Chem. 280 (48): 39677–80. doi:10.1074/jbc.C500287200. PMID 16204243. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.